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Aerosolized drug-loaded nanoparticles targeting migration inhibitory factors inhibit Pseudomonas aeruginosa-induced inflammation and biofilm formation.
Doroudian M, O'Neill A, O'Reilly C, Tynan A, Mawhinney L, McElroy A, Webster SS, MacLoughlin R, Volkov Y, E Armstrong M, A O'Toole G, Prina-Mello A, C Donnelly S. Doroudian M, et al. Among authors: o reilly c. Nanomedicine (Lond). 2020 Dec;15(30):2933-2953. doi: 10.2217/nnm-2020-0344. Epub 2020 Nov 26. Nanomedicine (Lond). 2020. PMID: 33241979 Free PMC article.
Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer.
Mawhinney L, Armstrong ME, O' Reilly C, Bucala R, Leng L, Fingerle-Rowson G, Fayne D, Keane MP, Tynan A, Maher L, Cooke G, Lloyd D, Conroy H, Donnelly SC. Mawhinney L, et al. Among authors: o reilly c. Mol Med. 2015 Apr 16;20(1):729-35. doi: 10.2119/molmed.2014.00136. Mol Med. 2015. PMID: 25826675 Free PMC article.
Macrophage migration inhibitory factor enhances Pseudomonas aeruginosa biofilm formation, potentially contributing to cystic fibrosis pathogenesis.
Tynan A, Mawhinney L, Armstrong ME, O'Reilly C, Kennedy S, Caraher E, Jülicher K, O'Dwyer D, Maher L, Schaffer K, Fabre A, McKone EF, Leng L, Bucala R, Bernhagen J, Cooke G, Donnelly SC. Tynan A, et al. Among authors: o reilly c. FASEB J. 2017 Nov;31(11):5102-5110. doi: 10.1096/fj.201700463R. Epub 2017 Aug 2. FASEB J. 2017. PMID: 28768722 Free PMC article.