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The following term was not found in PubMed: Kyratsou
Page 1
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe.
Habre W, Disma N, Virag K, Becke K, Hansen TG, Jöhr M, Leva B, Morton NS, Vermeulen PM, Zielinska M, Boda K, Veyckemans F; APRICOT Group of the European Society of Anaesthesiology Clinical Trial Network. Habre W, et al. Lancet Respir Med. 2017 May;5(5):412-425. doi: 10.1016/S2213-2600(17)30116-9. Epub 2017 Mar 28. Lancet Respir Med. 2017. PMID: 28363725
Recognition of abasic sites and single base bulges in DNA by a metalloinsertor.
Zeglis BM, Boland JA, Barton JK. Zeglis BM, et al. Biochemistry. 2009 Feb 10;48(5):839-49. doi: 10.1021/bi801885w. Biochemistry. 2009. PMID: 19146409 Free PMC article.
Here we discuss the binding properties with abasic sites and single base bulges of Rh(bpy)(2)(chrysi)(3+), a complex previously shown to bind thermodynamically destabilized mismatch sites via metalloinsertion. ...A wide variety of evidence, including strand scission asymme …
Here we discuss the binding properties with abasic sites and single base bulges of Rh(bpy)(2)(chrysi)(3+), a complex previously shown …
A Family of Rhodium Complexes with Selective Toxicity toward Mismatch Repair-Deficient Cancers.
Boyle KM, Barton JK. Boyle KM, et al. J Am Chem Soc. 2018 Apr 25;140(16):5612-5624. doi: 10.1021/jacs.8b02271. Epub 2018 Apr 17. J Am Chem Soc. 2018. PMID: 29620877 Free PMC article.
Here we describe DNA-binding and cellular studies with the second generation of Rh-O metalloinsertors in which an ancillary ligand is varied in both steric bulk and lipophilicity. These complexes, of the form [Rh(L)(chrysi)(PPO)](2+), all include the O-containing PPO ligan …
Here we describe DNA-binding and cellular studies with the second generation of Rh-O metalloinsertors in which an ancillary ligand is varied …
Binding of Ru(bpy)2(eilatin)2+ to matched and mismatched DNA.
Zeglis BM, Barton JK. Zeglis BM, et al. Inorg Chem. 2008 Jul 21;47(14):6452-7. doi: 10.1021/ic8006537. Epub 2008 Jun 25. Inorg Chem. 2008. PMID: 18576614 Free PMC article.
Competitive DNA photocleavage experiments employing a sequence-neutral metallointercalator, Rh(bpy)2(phi)(3+) (phi = 9,10-phenanthrenequinonediimine), and a mismatch-specific metalloinsertor, Rh(bpy)2(chrysi)(3+) (chrysi = chrysene-5,6-quinonediimine), reveal that t …
Competitive DNA photocleavage experiments employing a sequence-neutral metallointercalator, Rh(bpy)2(phi)(3+) (phi = 9,10-phenanthrenequinon …
Spectral and Structural Characterization of 5,6-Chrysenequinone Diimine Complexes of Rhodium(III): Evidence for a pH-Dependent Ligand Conformational Switch.
Jackson BA, Henling LM, Barton JK. Jackson BA, et al. Inorg Chem. 1999 Dec 27;38(26):6218-6224. doi: 10.1021/ic990824l. Inorg Chem. 1999. PMID: 11671336
Although similar in many respects, phi and chrysi complexes display distinctly different protonation behavior. The pK(a) values of chrysi complexes are as much as 1 unit lower than analogous phi compounds, and visible spectra of the chrysi complexes differ ma …
Although similar in many respects, phi and chrysi complexes display distinctly different protonation behavior. The pK(a) values of …
Luminescent properties of ruthenium(II) complexes with sterically expansive ligands bound to DNA defects.
McConnell AJ, Lim MH, Olmon ED, Song H, Dervan EE, Barton JK. McConnell AJ, et al. Inorg Chem. 2012 Nov 19;51(22):12511-20. doi: 10.1021/ic3019524. Epub 2012 Oct 31. Inorg Chem. 2012. PMID: 23113594 Free PMC article.
Design of the complexes sought to combine the mismatch specificity of sterically expansive metalloinsertors, such as [Rh(bpy)2(chrysi)](3+) (chrysi = chrysene-5,6-quinone diimine), and the light switch behavior of [Ru(bpy)2(dppz)](2+) (dppz = dipyrido[3,2-a:2',3'-c] …
Design of the complexes sought to combine the mismatch specificity of sterically expansive metalloinsertors, such as [Rh(bpy)2(chrysi …
In vivo anticancer activity of a rhodium metalloinsertor in the HCT116 xenograft tumor model.
Threatt SD, Synold TW, Wu J, Barton JK. Threatt SD, et al. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17535-17542. doi: 10.1073/pnas.2006569117. Epub 2020 Jul 13. Proc Natl Acad Sci U S A. 2020. PMID: 32661159 Free PMC article.
Mismatch repair (MMR) deficiencies are a hallmark of various cancers causing accumulation of DNA mutations and mismatches, which often results in chemotherapy resistance. Metalloinsertor complexes, including [Rh(chrysi)(phen)(PPO)]Cl(2) (Rh-PPO), specifically target DNA mi …
Mismatch repair (MMR) deficiencies are a hallmark of various cancers causing accumulation of DNA mutations and mismatches, which often resul …
Ru[(bpy)2(dppz)]2+ and Rh[(bpy)2(chrysi)]3+ targeting double strand DNA: the shape of the intercalating ligand tunes the free energy landscape of deintercalation.
Franco D, Vargiu AV, Magistrato A. Franco D, et al. Inorg Chem. 2014 Aug 4;53(15):7999-8008. doi: 10.1021/ic5008523. Epub 2014 Jul 23. Inorg Chem. 2014. PMID: 25055302
In this work we modeled the process of deintercalation from the major groove for delta-Ru[(bpy)2(dppz)](2+) (1) and delta-Rh[(bpy)2(chrysi)](3+) (2), prototypical examples of metallo-intercalators and metallo-insertors, respectively. By using advanced sampling techniques, …
In this work we modeled the process of deintercalation from the major groove for delta-Ru[(bpy)2(dppz)](2+) (1) and delta-Rh[(bpy)2(chrys …
A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition.
Junicke H, Hart JR, Kisko J, Glebov O, Kirsch IR, Barton JK. Junicke H, et al. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3737-42. doi: 10.1073/pnas.0537194100. Epub 2003 Feb 27. Proc Natl Acad Sci U S A. 2003. PMID: 12610209 Free PMC article.
Upon photoactivation, the complex promotes direct strand scission at single-base mismatch sites within the DNA duplex. As with the parent mismatch-specific reagent, [Rh(bpy)(2)(chrysi)](3+) [chrysene-5,6-quinone diimine (chrysi)], mismatch selectivity depends on the …
Upon photoactivation, the complex promotes direct strand scission at single-base mismatch sites within the DNA duplex. As with the parent mi …
Evolution of FMT - From early clinical to standardized treatments.
Servetas SL, Daschner PJ, Guyard C, Thomas V, Affagard H, Sergaki C, Sokol H, Wargo JA, Wu GD, Sabot P. Servetas SL, et al. Biologicals. 2022 Apr;76:31-35. doi: 10.1016/j.biologicals.2022.01.004. Epub 2022 Jan 24. Biologicals. 2022. PMID: 35086768
38 results