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Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.
Zang J, Peters F, Cambet Y, Cifuentes-Pagano E, Hissabu MMS, Dustin CM, Svensson LH, Olesen MM, Poulsen MFL, Jacobsen S, Tuelung PS, Narayanan D, Langkilde AE, Gajhede M, Pagano PJ, Jaquet V, Vilhardt F, Bach A. Zang J, et al. Among authors: dustin cm. J Med Chem. 2023 Nov 9;66(21):14963-15005. doi: 10.1021/acs.jmedchem.3c01548. Epub 2023 Oct 19. J Med Chem. 2023. PMID: 37857466
Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
Schiffers C, van de Wetering C, Bauer RA, Habibovic A, Hristova M, Dustin CM, Lambrichts S, Vacek PM, Wouters EF, Reynaert NL, van der Vliet A. Schiffers C, et al. Among authors: dustin cm. JCI Insight. 2021 Jan 25;6(2):e142189. doi: 10.1172/jci.insight.142189. JCI Insight. 2021. PMID: 33301419 Free PMC article.
Direct cysteine sulfenylation drives activation of the Src kinase.
Heppner DE, Dustin CM, Liao C, Hristova M, Veith C, Little AC, Ahlers BA, White SL, Deng B, Lam YW, Li J, van der Vliet A. Heppner DE, et al. Among authors: dustin cm. Nat Commun. 2018 Oct 30;9(1):4522. doi: 10.1038/s41467-018-06790-1. Nat Commun. 2018. PMID: 30375386 Free PMC article.
Profibrotic epithelial TGF-β1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN.
Veith C, Hristova M, Danyal K, Habibovic A, Dustin CM, McDonough JE, Vanaudenaerde BM, Kreuter M, Schneider MA, Kahn N, van Schooten FJ, Boots AW, van der Vliet A. Veith C, et al. Among authors: dustin cm. Am J Physiol Lung Cell Mol Physiol. 2021 Mar 1;320(3):L356-L367. doi: 10.1152/ajplung.00444.2019. Epub 2020 Dec 16. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33325804 Free PMC article.
17 results