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Covalent inhibition of NSD1 histone methyltransferase.
Huang H, Howard CA, Zari S, Cho HJ, Shukla S, Li H, Ndoj J, González-Alonso P, Nikolaidis C, Abbott J, Rogawski DS, Potopnyk MA, Kempinska K, Miao H, Purohit T, Henderson A, Mapp A, Sulis ML, Ferrando A, Grembecka J, Cierpicki T. Huang H, et al. Among authors: howard ca. Nat Chem Biol. 2020 Dec;16(12):1403-1410. doi: 10.1038/s41589-020-0626-6. Epub 2020 Aug 31. Nat Chem Biol. 2020. PMID: 32868895 Free PMC article.
Utilization of alkyne bioconjugations to modulate protein function.
Maza JC, Howard CA, Vipani MA, Travis CR, Young DD. Maza JC, et al. Among authors: howard ca. Bioorg Med Chem Lett. 2017 Jan 1;27(1):30-33. doi: 10.1016/j.bmcl.2016.11.041. Epub 2016 Nov 16. Bioorg Med Chem Lett. 2017. PMID: 27894869 Free PMC article.