Cardiac Biomarkers and Risk Scores in Relation with History of Atherosclerotic Cardiovascular Disease in Patients Admitted with COVID-19: The Experience of an Eastern European Center

Catalina Lionte; Victorita Sorodoc; Raluca Ecaterina Haliga; Cristina Bologa; Alexandr Ceasovschih; Oana Sirbu; Victoria Gorciac; Andrei-Costin Chelariu; Alexandra Stoica; Roxana Elena Tocila; Minerva Codruta Badescu; Irina-Iuliana Costache; Christiana Brigitte Sandu; Elisabeta Jaba; Laurentiu Sorodoc

doi:10.3390/jcm11195671

Cardiac Biomarkers and Risk Scores in Relation with History of Atherosclerotic Cardiovascular Disease in Patients Admitted with COVID-19: The Experience of an Eastern European Center

J Clin Med. 2022 Sep 26;11(19):5671. doi: 10.3390/jcm11195671.

Authors

Catalina Lionte^{1

2}, Victorita Sorodoc^{1

2}, Raluca Ecaterina Haliga^{1

2}, Cristina Bologa^{1

2}, Alexandr Ceasovschih^{1

2}, Oana Sirbu^{1

2}, Victoria Gorciac^{2

3}, Andrei-Costin Chelariu^{2

4}, Alexandra Stoica^{1

2}, Roxana Elena Tocila^{2

5}, Minerva Codruta Badescu^{1

6}, Irina-Iuliana Costache⁷, Christiana Brigitte Sandu⁸, Elisabeta Jaba⁸, Laurentiu Sorodoc^{1

2}

Affiliations

¹ Internal Medicine Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
² Second Internal Medicine Clinic, "Sf. Spiridon" Emergency Clinical County Hospital, 700106 Iasi, Romania.
³ Rheumatology Department, Clinical Recovery Hospital, 700661 Iasi, Romania.
⁴ Hematology Department, Regional Institute of Oncology, 700483 Iasi, Romania.
⁵ Department of Cardiology, Cardiovascular Diseases Institute "Prof. Dr. George I.M. Georgescu", 700503 Iasi, Romania.
⁶ III Internal Medicine Clinic, "St. Spiridon" County Emergency Clinical Hospital, 1 Independence Boulevard, 700111 Iasi, Romania.
⁷ Department of Internal Medicine (Cardiology), "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
⁸ Statistics Department, Faculty of Economics and Business Administration, "Alexandru Ioan Cuza" University, 700506 Iasi, Romania.

Abstract

Background: Data regarding the combined prognostic role of biomarkers and risk scores in relation with the history of atherosclerotic cardiovascular disease (ASCVD) in COVID-19 patients are lacking.

Methods: The aim of this observational cohort study was to evaluate the combined prognostic value of N-terminal pro B-type natriuretic peptide (NT-pro BNP), troponin and risk scores in relation with ASCVD history in hospitalized COVID-19 patients. The primary composite endpoint was Intensive Care Unit (ICU) admission and death.

Results: From April 2020 to June 2022, 1066 consecutive COVID-19 patients with available biomarkers upon admission were included. During a median follow-up period of 12 days, 176 patients (16.5%) died. Independent predictors of ICU admission and death in patients with ASCVD were NT-pro BNP (HR 2.63; 95% CI, 1.65-4.18) and troponin (HR 1.51; 95% CI, 1.13-2.03). In patients without ASCVD, only NT-pro BNP was predictive for the primary endpoint (HR 1.66; 95% CI, 1.10-2.53). This remained significant after adjustment for other relevant covariates (HR 3.54; 95% CI, 1.98-6.33) in patients with ASCVD and in patients without ASCVD (HR 1.82; 95% CI, 1.02-3.26).

Conclusions: These data showed the combined prognostic accuracy of NT-pro BNP and troponin in relation with ASCVD history for ICU admission and death in COVID-19 patients.

Keywords: COVID-19; Charlson comorbidity index; CoLACD score; N-terminal pro-B type natriuretic peptide; NEWS2 score; atherosclerotic cardiovascular disease; troponin I.

Grants and funding

This research received no external funding.