Active conformation of the p97-p47 unfoldase complex.
Xu Y, Han H, Cooney I, Guo Y, Moran NG, Zuniga NR, Price JC, Hill CP, Shen PS.
Xu Y, et al.
Nat Commun. 2022 May 12;13(1):2640. doi: 10.1038/s41467-022-30318-3.
Nat Commun. 2022.
PMID: 35552390
Free PMC article.
These findings support the model that p97 utilizes a "hand-over-hand" mechanism in which two residues of the substrate are translocated for hydrolysis of two ATPs, one in each of the two p97 AAA ATPase rings. Proteomics analysis supports the model that one p97 complex can …
These findings support the model that p97 utilizes a "hand-over-hand" mechanism in which two residues of the substrate are translocated for …