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Page 1
Native starch as in situ binder for continuous twin screw wet granulation.
Vandevivere L, Portier C, Vanhoorne V, Häusler O, Simon D, De Beer T, Vervaet C. Vandevivere L, et al. Int J Pharm. 2019 Nov 25;571:118760. doi: 10.1016/j.ijpharm.2019.118760. Epub 2019 Oct 14. Int J Pharm. 2019. PMID: 31622742
The use of native starch as in situ binder in a continuous twin screw wet granulation process was studied. ...The study showed that native starch can be considered as a promising in situ binder for continuous twin screw wet granulation of a poorly soluble formulatio …
The use of native starch as in situ binder in a continuous twin screw wet granulation process was studied. ...The study showed that n …
New intracellular activities of matrix metalloproteinases shine in the moonlight.
Jobin PG, Butler GS, Overall CM. Jobin PG, et al. Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):2043-2055. doi: 10.1016/j.bbamcr.2017.05.013. Epub 2017 May 16. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28526562 Free article. Review.
Matrix metalloproteinases (MMPs), classically viewed as degraders of the extracellular matrix (ECM) responsible for matrix protein turnover, are more recently recognized as regulators of a range of extracellular bioactive molecules including chemokines, cytokines, and their bi …
Matrix metalloproteinases (MMPs), classically viewed as degraders of the extracellular matrix (ECM) responsible for matrix protein turnover, …
Computer-guided binding mode identification and affinity improvement of an LRR protein binder without structure determination.
Choi Y, Jeong S, Choi JM, Ndong C, Griswold KE, Bailey-Kellogg C, Kim HS. Choi Y, et al. PLoS Comput Biol. 2020 Aug 31;16(8):e1008150. doi: 10.1371/journal.pcbi.1008150. eCollection 2020 Aug. PLoS Comput Biol. 2020. PMID: 32866140 Free PMC article.
As proof-of-concept, we used a leucine-rich repeat (LRR) protein binder, called a repebody (Rb), that specifically recognizes human IgG1 (hIgG1). ...
As proof-of-concept, we used a leucine-rich repeat (LRR) protein binder, called a repebody (Rb), that specifically recognizes human I …
Reducing Discomfort After Cesarean Birth Using Abdominal Binders.
Tussey C, Kelly LA, Oja KJ, Bay RC, Makarova N. Tussey C, et al. MCN Am J Matern Child Nurs. 2019 Nov/Dec;44(6):310-316. doi: 10.1097/NMC.0000000000000571. MCN Am J Matern Child Nurs. 2019. PMID: 31490194 Clinical Trial.
On postoperative day 2, women in the binder group used more ibuprofen (p = .002) and acetaminophen (p = .027) than the control group. ...As a nursing intervention, abdominal binders may offer women a safe nonpharmacologic option to provide postoperative comfort....
On postoperative day 2, women in the binder group used more ibuprofen (p = .002) and acetaminophen (p = .027) than the control group. …
New developments in the management of hyperphosphatemia in chronic kidney disease.
McIntyre CW. McIntyre CW. Semin Dial. 2007 Jul-Aug;20(4):337-41. doi: 10.1111/j.1525-139X.2007.00306.x. Semin Dial. 2007. PMID: 17635825 Review.
Given the limitations of restricting phosphate in the diet and the inadequate removal by conventional dialysis regimes, nephrologists rely on the use of additional medications to control serum levels (currently oral phosphate binders). This review focuses on new agents and …
Given the limitations of restricting phosphate in the diet and the inadequate removal by conventional dialysis regimes, nephrologists rely o …
Hydantoin based inhibitors of MMP13--discovery of AZD6605.
De Savi C, Waterson D, Pape A, Lamont S, Hadley E, Mills M, Page KM, Bowyer J, Maciewicz RA. De Savi C, et al. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4705-12. doi: 10.1016/j.bmcl.2013.05.089. Epub 2013 Jun 10. Bioorg Med Chem Lett. 2013. PMID: 23810497
Continuous melt granulation: Influence of process and formulation parameters upon granule and tablet properties.
Monteyne T, Vancoillie J, Remon JP, Vervaet C, De Beer T. Monteyne T, et al. Eur J Pharm Biopharm. 2016 Oct;107:249-62. doi: 10.1016/j.ejpb.2016.07.021. Epub 2016 Jul 20. Eur J Pharm Biopharm. 2016. PMID: 27449628
The aim of this study was to examine the relationship between formulation-parameters (type binder, binder concentration, drug-binder miscibility), process-parameters (screw speed, powder feed rate and granulation temperature), granule properties (size, size d …
The aim of this study was to examine the relationship between formulation-parameters (type binder, binder concentration, drug- …
The use of rheology to elucidate the granulation mechanisms of a miscible and immiscible system during continuous twin-screw melt granulation.
Monteyne T, Heeze L, Mortier ST, Oldörp K, Nopens I, Remon JP, Vervaet C, De Beer T. Monteyne T, et al. Int J Pharm. 2016 Aug 20;510(1):271-84. doi: 10.1016/j.ijpharm.2016.06.055. Epub 2016 Jun 29. Int J Pharm. 2016. PMID: 27374203
This allowed to use a rheometer to gain knowledge of the material behavior during hot melt processing of an immiscible drug-binder blend. However, miscibility of a drug-binder formulation and drug-binder interactions appear to influence the rheological proper …
This allowed to use a rheometer to gain knowledge of the material behavior during hot melt processing of an immiscible drug-binder bl …
Iron-magnesium hydroxycarbonate (fermagate): a novel non-calcium-containing phosphate binder for the treatment of hyperphosphatemia in chronic hemodialysis patients.
McIntyre CW, Pai P, Warwick G, Wilkie M, Toft AJ, Hutchison AJ. McIntyre CW, et al. Clin J Am Soc Nephrol. 2009 Feb;4(2):401-9. doi: 10.2215/CJN.02630608. Epub 2009 Jan 21. Clin J Am Soc Nephrol. 2009. PMID: 19158369 Free PMC article. Clinical Trial.
BACKGROUND AND OBJECTIVES: This phase II study tested the safety and efficacy of fermagate, a calcium-free iron and magnesium hydroxycarbonate binder, for treating hyperphosphatemia in hemodialysis patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A randomized, …
BACKGROUND AND OBJECTIVES: This phase II study tested the safety and efficacy of fermagate, a calcium-free iron and magnesium hydroxycarbona …
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