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chiral saharan
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Chirag Saharan
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Synthesis and structure-activity relationship studies of cruzain and rhodesain inhibitors.
Eur J Med Chem. 2018 Sep 5;157:1426-1459. doi: 10.1016/j.ejmech.2018.08.079. Epub 2018 Aug 31.
Eur J Med Chem. 2018.
PMID: 30282318
Review.
Chagas disease and Human African trypanosomiasis (HAT) are important public health issues in Latin American and sub-Saharan African countries, respectively, and are responsible for a significant number of deaths. ...Modern approaches such as the asymmetric addition of subs …
Chagas disease and Human African trypanosomiasis (HAT) are important public health issues in Latin American and sub-Saharan African c …
Species-Specific Adaptations of Trypanosome Morphology and Motility to the Mammalian Host.
Bargul JL, Jung J, McOdimba FA, Omogo CO, Adung'a VO, Krüger T, Masiga DK, Engstler M.
Bargul JL, et al.
PLoS Pathog. 2016 Feb 12;12(2):e1005448. doi: 10.1371/journal.ppat.1005448. eCollection 2016 Feb.
PLoS Pathog. 2016.
PMID: 26871910
Free PMC article.
Infections of cattle cause an enormous socio-economic burden in sub-Saharan Africa. A hallmark of the trypanosome lifestyle is the flagellate's incessant motion. ...Three-dimensional analyses of the trypanosomes expose a high degree of dynamic pleomorphism, typified by the …
Infections of cattle cause an enormous socio-economic burden in sub-Saharan Africa. A hallmark of the trypanosome lifestyle is the fl …
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The molecular dynamics of Trypanosoma brucei UDP-galactose 4'-epimerase: a drug target for African sleeping sickness.
Friedman AJ, Durrant JD, Pierce LC, McCorvie TJ, Timson DJ, McCammon JA.
Friedman AJ, et al.
Chem Biol Drug Des. 2012 Aug;80(2):173-81. doi: 10.1111/j.1747-0285.2012.01392.x. Epub 2012 May 2.
Chem Biol Drug Des. 2012.
PMID: 22487100
Free PMC article.
During the past century, several epidemics of human African trypanosomiasis, a deadly disease caused by the protist Trypanosoma brucei, have afflicted sub-Saharan Africa. Over 10 000 new victims are reported each year, with hundreds of thousands more at risk. ...The sample …
During the past century, several epidemics of human African trypanosomiasis, a deadly disease caused by the protist Trypanosoma brucei, have …
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