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Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB.
Nat Commun. 2020 Nov 4;11(1):5565. doi: 10.1038/s41467-020-19397-2.
Nat Commun. 2020.
PMID: 33149158
Free PMC article.
Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump.
Grimsey EM, Fais C, Marshall RL, Ricci V, Ciusa ML, Stone JW, Ivens A, Malloci G, Ruggerone P, Vargiu AV, Piddock LJV.
Grimsey EM, et al. Among authors: fais c.
mBio. 2020 Jun 2;11(3):e00465-20. doi: 10.1128/mBio.00465-20.
mBio. 2020.
PMID: 32487753
Free PMC article.
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Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from Salmonella.
Johnson RM, Fais C, Parmar M, Cheruvara H, Marshall RL, Hesketh SJ, Feasey MC, Ruggerone P, Vargiu AV, Postis VLG, Muench SP, Bavro VN.
Johnson RM, et al. Among authors: fais c.
Microorganisms. 2020 Jun 23;8(6):943. doi: 10.3390/microorganisms8060943.
Microorganisms. 2020.
PMID: 32585951
Free PMC article.
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