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Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity.
Larsen MD, de Graaf EL, Sonneveld ME, Plomp HR, Nouta J, Hoepel W, Chen HJ, Linty F, Visser R, Brinkhaus M, Šuštić T, de Taeye SW, Bentlage AEH, Toivonen S, Koeleman CAM, Sainio S, Kootstra NA, Brouwer PJM, Geyer CE, Derksen NIL, Wolbink G, de Winther M, Sanders RW, van Gils MJ, de Bruin S, Vlaar APJ; Amsterdam UMC COVID-19; biobank study group; Rispens T, den Dunnen J, Zaaijer HL, Wuhrer M, Ellen van der Schoot C, Vidarsson G. Larsen MD, et al. Among authors: geyer ce. Science. 2021 Feb 26;371(6532):eabc8378. doi: 10.1126/science.abc8378. Epub 2020 Dec 23. Science. 2021. PMID: 33361116 Free PMC article.
The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees.
Van Coillie J, Pongracz T, Rahmöller J, Chen HJ, Geyer CE, van Vught LA, Buhre JS, Šuštić T, van Osch TLJ, Steenhuis M, Hoepel W, Wang W, Lixenfeld AS, Nouta J, Keijzer S, Linty F, Visser R, Larsen MD, Martin EL, Künsting I, Lehrian S, von Kopylow V, Kern C, Lunding HB, de Winther M, van Mourik N, Rispens T, Graf T, Slim MA, Minnaar RP, Bomers MK, Sikkens JJ, Vlaar APJ, van der Schoot CE, den Dunnen J, Wuhrer M, Ehlers M, Vidarsson G; Fatebenefratelli-Sacco Infectious Diseases Physicians group; UMC COVID-19 S3/HCW study group. Van Coillie J, et al. Among authors: geyer ce. EBioMedicine. 2023 Jan;87:104408. doi: 10.1016/j.ebiom.2022.104408. Epub 2022 Dec 16. EBioMedicine. 2023. PMID: 36529104 Free PMC article.