Salecan diet increases short chain fatty acids and enriches beneficial microbiota in the mouse cecum

Mengyi Zhou; Chuanliang Pu; Lin Xia; Xiaohong Yu; Bin Zhu; Rui Cheng; Linxiang Xu; Jianfa Zhang

doi:10.1016/j.carbpol.2013.10.091

Salecan diet increases short chain fatty acids and enriches beneficial microbiota in the mouse cecum

Carbohydr Polym. 2014 Feb 15:102:772-9. doi: 10.1016/j.carbpol.2013.10.091. Epub 2013 Nov 6.

Authors

Mengyi Zhou¹, Chuanliang Pu², Lin Xia³, Xiaohong Yu⁴, Bin Zhu⁵, Rui Cheng⁶, Linxiang Xu⁷, Jianfa Zhang⁸

Affiliations

¹ Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: zhoumengyi1986@gmail.com.
² College of Life Science, Nanjing Agricultural University, 1 Weigang Street, Nanjing 210095, China. Electronic address: 2010116049@njau.edu.cn.
³ Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: xialinfzdx@126.com.
⁴ Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: yu198891@sina.com.
⁵ Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: zhubin960311@163.com.
⁶ Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: chengrui.1988@163.com.
⁷ Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: xulinxiang1988@yahoo.cn.
⁸ Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China; College of Life Science, Nanjing University, 22 Hankou Road, Nanjing 210093, China. Electronic address: jfzhang@mail.njust.edu.cn.

PMID: 24507346
DOI: 10.1016/j.carbpol.2013.10.091

Abstract

Salecan, a linear extracellular polysaccharide consisting of β-(1,3)-D-glucan, has potential applications in the food industry due to its excellent toxicological profile and rheological properties. The aim of the present study was to evaluate the effects of dietary supplementation with 8% Salecan on the gastrointestinal microbiota in mice. In the Salecan group, the following significant differences (p<0.05) from the cellulose group were found: increased body weight gain, greater mass of cecum and cecal contents, and higher butyrate concentrations in the cecal and colonic contents at wk 4. Moreover, populations of Lactobacillus and Bifidobacterium increased 3- and 6-fold, respectively, in the cecal contents of mice consuming Salecan. These results suggest that the dietary incorporation of Salecan, by providing SCFAs and increasing beneficial microbiota, may be beneficial in improving gastrointestinal health, and have relevance to the use of Salecan as a dietary supplement for human consumption.

Keywords: Bifidobacteria; Lactobacilli; Mice; PCR-DGGE; SCFA; Salecan.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bacteria / classification
Cecum / microbiology*
Diet*
Electrophoresis, Polyacrylamide Gel
Fatty Acids, Volatile / metabolism*
Mice
Mice, Inbred C57BL
Microbiota*
Phylogeny
Polymerase Chain Reaction
Weight Gain
beta-Glucans / administration & dosage*

Substances

Fatty Acids, Volatile
beta-Glucans
salecan