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Showing results for chelator mog
Search for Chelapro Mog instead (2 results)
alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination.
Kuhbandner K, Hoffmann A, González Alvarado MN, Seyler L, Bäuerle T, Winkler J, Linker RA. Kuhbandner K, et al. J Mol Neurosci. 2020 Jul;70(7):1038-1049. doi: 10.1007/s12031-020-01498-8. Epub 2020 Mar 23. J Mol Neurosci. 2020. PMID: 32207050 Free PMC article.
In the present study, the effect of aSyn deficiency on de- and regenerative events in the CNS was analyzed by using two different demyelinating animal models: chronic MOG(35-55)-induced experimental autoimmune encephalomyelitis (EAE) and the cuprizone model. ...
In the present study, the effect of aSyn deficiency on de- and regenerative events in the CNS was analyzed by using two different demyelinat …
Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model.
Wang J, Sui RX, Miao Q, Wang Q, Song LJ, Yu JZ, Li YH, Xiao BG, Ma CG. Wang J, et al. Clin Immunol. 2019 Apr;201:35-47. doi: 10.1016/j.clim.2019.01.006. Epub 2019 Jan 17. Clin Immunol. 2019. PMID: 30660624 Retracted.
HF improved behavioral abnormality and reduced myelin damage in the corpus callosum. Splenic atrophy and myelin oligodendrocyte glycoprotein (MOG) antibody were observed in CPZ model, which were partially restored and obviously inhibited by HF, therefore reducing pathogeni …
HF improved behavioral abnormality and reduced myelin damage in the corpus callosum. Splenic atrophy and myelin oligodendrocyte glycoprotein …
Diverse Gene Expressions in the Prediction of Cuprizone-Induced Demyelination.
Han SR, Kang YH, Yoo SM, Lee MS, Lee SH. Han SR, et al. Neurotox Res. 2020 Mar;37(3):732-742. doi: 10.1007/s12640-019-00154-3. Epub 2020 Jan 8. Neurotox Res. 2020. PMID: 31916130
Our results demonstrated that CPZ-induced demyelination induces apparent alterations in the expression of most of the myelin-related genes, including the 6 key genes MBP, MAG, and MOG and GFAP, CXCR4, and NgR, which were observed to be downregulated and upregulated, respec …
Our results demonstrated that CPZ-induced demyelination induces apparent alterations in the expression of most of the myelin-related genes, …
IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity.
Avloniti M, Evangelidou M, Gomini M, Loupis T, Emmanouil M, Mitropoulou A, Tselios T, Lassmann H, Gruart A, Delgado-García JM, Probert L, Kyrargyri V. Avloniti M, et al. J Neuroinflammation. 2024 Jan 27;21(1):34. doi: 10.1186/s12974-024-03023-9. J Neuroinflammation. 2024. PMID: 38279130 Free PMC article.
METHODS: We used constitutive MphiIKKbetakappaomicron mice, in which depletion of IKKbeta, the main activating kinase of NF-kappaB, was global to CNS and peripheral macrophages, and mugiotakappakappabetaKO mice, in which depletion was inducible and specific to CNS macrophages by …
METHODS: We used constitutive MphiIKKbetakappaomicron mice, in which depletion of IKKbeta, the main activating kinase of NF-kappaB, was glob …
Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination.
Sui RX, Miao Q, Wang J, Wang Q, Song LJ, Yu JW, Cao L, Xiao W, Xiao BG, Ma CG. Sui RX, et al. Int Immunopharmacol. 2019 Jan;66:69-81. doi: 10.1016/j.intimp.2018.09.041. Epub 2018 Nov 13. Int Immunopharmacol. 2019. PMID: 30445309
We for the first time found that CPZ caused the splenic atrophy and induced the formation of myelin oligodendrocyte glycoprotein (MOG) antibody, which was attenuated by Bilobalide. Thus, Bilobalide decreased the loss of O4+ oligodendrocytes possibly through MOG anti …
We for the first time found that CPZ caused the splenic atrophy and induced the formation of myelin oligodendrocyte glycoprotein (MOG …
A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis.
Offen D, Gilgun-Sherki Y, Barhum Y, Benhar M, Grinberg L, Reich R, Melamed E, Atlas D. Offen D, et al. J Neurochem. 2004 Jun;89(5):1241-51. doi: 10.1111/j.1471-4159.2004.02428.x. J Neurochem. 2004. PMID: 15147517 Free article.
Here we report that N-acetylcysteine amide (AD4) crosses the blood-brain barrier (BBB), chelates Cu(2+), which catalyzes free radical formation, and prevents ROS-induced activation of JNK, p38 and MMP-9. ...In agreement with the in vitro studies, we propose that ROS scaven …
Here we report that N-acetylcysteine amide (AD4) crosses the blood-brain barrier (BBB), chelates Cu(2+), which catalyzes free radical …
Influx of T cells into corpus callosum increases axonal injury, but does not change the course of remyelination in toxic demyelination.
Yilmaz EN, Albrecht S, Groll K, Thomas C, Wallhorn L, Herold M, Hucke S, Klotz L, Kuhlmann T. Yilmaz EN, et al. Glia. 2023 Apr;71(4):991-1001. doi: 10.1002/glia.24319. Epub 2022 Dec 13. Glia. 2023. PMID: 36511515
In earlier studies, T cells either promoted or impaired RM. Here, we used the combined cuprizone/MOG-EAE model to further dissect the functional role of T cells for RM. The combination of MOG immunization with cuprizone feeding targeted T cells to the corpus callosu …
In earlier studies, T cells either promoted or impaired RM. Here, we used the combined cuprizone/MOG-EAE model to further dissect the …
Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically-induced and immune-mediated mouse models of multiple sclerosis.
Titus HE, Xu H, Robinson AP, Patel PA, Chen Y, Fantini D, Eaton V, Karl M, Garrison ED, Rose IVL, Chiang MY, Podojil JR, Balabanov R, Liddelow SA, Miller RH, Popko B, Miller SD. Titus HE, et al. Glia. 2022 Oct;70(10):1950-1970. doi: 10.1002/glia.24231. Epub 2022 Jul 9. Glia. 2022. PMID: 35809238 Free PMC article.
More relevant to treatment of MS, we show that digoxin treatment of mice with established MOG(35-55) -induced Th1/Th17-mediated chronic EAE combined with tolerance induced by the i.v. infusion of biodegradable poly(lactide-co-glycolide) nanoparticles coupled with MOG …
More relevant to treatment of MS, we show that digoxin treatment of mice with established MOG(35-55) -induced Th1/Th17-mediated chron …
Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model.
Wang Z, Baharani A, Wei Z, Truong D, Bi X, Wang F, Li XM, Verge VMK, Zhang Y. Wang Z, et al. Clin Exp Pharmacol Physiol. 2021 Aug;48(8):1090-1102. doi: 10.1111/1440-1681.13490. Epub 2021 Apr 7. Clin Exp Pharmacol Physiol. 2021. PMID: 33638234
Immunohistochemical and immunoblotting data showed enhanced myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein expressions (MOG) in the prefrontal cortex of mice with LFMS treatment, supporting that myelin repair was promoted. ...
Immunohistochemical and immunoblotting data showed enhanced myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein expressions ( …
Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model.
Choi BY, Jang BG, Kim JH, Seo JN, Wu G, Sohn M, Chung TN, Suh SW. Choi BY, et al. Neurobiol Dis. 2013 Jun;54:382-91. doi: 10.1016/j.nbd.2013.01.012. Epub 2013 Jan 27. Neurobiol Dis. 2013. PMID: 23360710
The present study aimed to evaluate the therapeutic potential of clioquinol (CQ), a metal chelator, on multiple sclerosis pathogenesis. Experimental autoimmune encephalomyelitis was induced by immunization with myelin oligodendrocyte glycoprotein (MOG(35-55)) in fem …
The present study aimed to evaluate the therapeutic potential of clioquinol (CQ), a metal chelator, on multiple sclerosis pathogenesi …
41 results