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1968 4
1969 1
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1971 7
1972 3
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1974 2
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1978 22
1979 21
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1988 507
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1999 1354
2000 1461
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2007 2526
2008 2610
2009 2622
2010 2883
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2020 7501
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104,007 results

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Page 1
Showing results for channel center
Your search for Chanel Venter retrieved no results
Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes.
Hu M, Li P, Wang C, Feng X, Geng Q, Chen W, Marthi M, Zhang W, Gao C, Reid W, Swanson J, Du W, Hume RI, Xu H. Hu M, et al. Cell. 2022 Jun 23;185(13):2292-2308.e20. doi: 10.1016/j.cell.2022.05.021. Cell. 2022. PMID: 35750034 Free PMC article.
Here we show that TMEM175, a genetic risk factor for Parkinson's disease (PD), mediates the lysosomal H(+) leak by acting as a proton-activated, proton-selective channel on the lysosomal membrane (LyPAP). Acidification beyond the normal range potently activated LyPAP to te …
Here we show that TMEM175, a genetic risk factor for Parkinson's disease (PD), mediates the lysosomal H(+) leak by acting as a proton-activa …
Ketamine blocks bursting in the lateral habenula to rapidly relieve depression.
Yang Y, Cui Y, Sang K, Dong Y, Ni Z, Ma S, Hu H. Yang Y, et al. Nature. 2018 Feb 14;554(7692):317-322. doi: 10.1038/nature25509. Nature. 2018. PMID: 29446381
Here we show that blockade of NMDAR-dependent bursting activity in the 'anti-reward center', the lateral habenula (LHb), mediates the rapid antidepressant actions of ketamine in rat and mouse models of depression. ...Pharmacology and modelling experiments reveal that LHb b …
Here we show that blockade of NMDAR-dependent bursting activity in the 'anti-reward center', the lateral habenula (LHb), mediates the …
The Piezo channel is central to the mechano-sensitive channel complex in the mammalian inner ear.
Lee JH, Perez-Flores MC, Park S, Kim HJ, Chen Y, Kang M, Kersigo J, Choi J, Thai PN, Woltz R, Perez-Flores DC, Perkins G, Sihn CR, Trinh P, Zhang XD, Sirish P, Dong Y, Feng WW, Pessah IN, Dixon RE, Sokolowski B, Fritzsch B, Chiamvimonvat N, Yamoah EN. Lee JH, et al. Res Sq [Preprint]. 2023 Jul 12:rs.3.rs-2287052. doi: 10.21203/rs.3.rs-2287052/v1. Res Sq. 2023. PMID: 37502846 Free PMC article. Updated. Preprint.
Of all the senses, hearing and balance, which rely on mechanosensation, are the fastest sensory signals transmitted to the central nervous system. The mechanoelectrical transducer (MET) channel in hair cells is the entryway for the sound-balance-brain interface, but the …
Of all the senses, hearing and balance, which rely on mechanosensation, are the fastest sensory signals transmitted to the central nervous s …
Noncanonical Ion Channel Behaviour in Pain.
Ciotu CI, Tsantoulas C, Meents J, Lampert A, McMahon SB, Ludwig A, Fischer MJM. Ciotu CI, et al. Int J Mol Sci. 2019 Sep 15;20(18):4572. doi: 10.3390/ijms20184572. Int J Mol Sci. 2019. PMID: 31540178 Free PMC article. Review.
Ion channels contribute fundamental properties to cell membranes. Although highly diverse in conductivity, structure, location, and function, many of them can be regulated by common mechanisms, such as voltage or (de-)phosphorylation. Primarily considering ion channels …
Ion channels contribute fundamental properties to cell membranes. Although highly diverse in conductivity, structure, location, and f …
Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8.
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N. Huang X, et al. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2208211119. doi: 10.1073/pnas.2208211119. Epub 2022 Jul 19. Proc Natl Acad Sci U S A. 2022. PMID: 35858452 Free PMC article.
The dorsal root ganglia-localized voltage-gated sodium (Na(v)) channel Na(v)1.8 represents a promising target for developing next-generation analgesics. ...Our structure-guided functional characterizations show that two nonligand binding residues, Thr397 on S6(I) and Gly14 …
The dorsal root ganglia-localized voltage-gated sodium (Na(v)) channel Na(v)1.8 represents a promising target for developing next-gen …
TACAN Is an Ion Channel Involved in Sensing Mechanical Pain.
Beaulieu-Laroche L, Christin M, Donoghue A, Agosti F, Yousefpour N, Petitjean H, Davidova A, Stanton C, Khan U, Dietz C, Faure E, Fatima T, MacPherson A, Mouchbahani-Constance S, Bisson DG, Haglund L, Ouellet JA, Stone LS, Samson J, Smith MJ, Ask K, Ribeiro-da-Silva A, Blunck R, Poole K, Bourinet E, Sharif-Naeini R. Beaulieu-Laroche L, et al. Cell. 2020 Mar 5;180(5):956-967.e17. doi: 10.1016/j.cell.2020.01.033. Epub 2020 Feb 20. Cell. 2020. PMID: 32084332 Free article.
Purification and reconstitution of TACAN in synthetic lipids generates a functional ion channel. Finally, a nociceptor-specific inducible knockout of TACAN decreases the mechanosensitivity of nociceptors and reduces behavioral responses to painful mechanical stimuli but no …
Purification and reconstitution of TACAN in synthetic lipids generates a functional ion channel. Finally, a nociceptor-specific induc …
Data Center Four-Channel Multimode Interference Multiplexer Using Silicon Nitride Technology.
Isakov O, Frishman A, Malka D. Isakov O, et al. Nanomaterials (Basel). 2024 Mar 8;14(6):486. doi: 10.3390/nano14060486. Nanomaterials (Basel). 2024. PMID: 38535634 Free PMC article.
In response to this challenge, we propose an innovative design for a four-channel silicon nitride (Si(3)N(4)) MMI coupler with a compact footprint. ...Leveraging Si(3)N(4) material and waveguide inputs and output tapers minimizes light reflection from the MMI coupler at th …
In response to this challenge, we propose an innovative design for a four-channel silicon nitride (Si(3)N(4)) MMI coupler with a comp …
A new polymodal gating model of the proton-activated chloride channel.
Zhao P, Tang C, Yang Y, Xiao Z, Perez-Miller S, Zhang H, Luo G, Liu H, Li Y, Liao Q, Yang F, Dong H, Khanna R, Liu Z. Zhao P, et al. PLoS Biol. 2023 Sep 15;21(9):e3002309. doi: 10.1371/journal.pbio.3002309. eCollection 2023 Sep. PLoS Biol. 2023. PMID: 37713449 Free PMC article.
However, at higher concentrations, C77304 acted as a weak inhibitor, suppressing channel activity. This dual function was achieved by interacting with 2 modulatory sites of the channel, each with different affinities and dependencies on the channel's s …
However, at higher concentrations, C77304 acted as a weak inhibitor, suppressing channel activity. This dual function was achieved by …
Ion channel regulation by protein S-acylation.
Shipston MJ. Shipston MJ. J Gen Physiol. 2014 Jun;143(6):659-78. doi: 10.1085/jgp.201411176. Epub 2014 May 12. J Gen Physiol. 2014. PMID: 24821965 Free PMC article. Review.
S-acylation can control the two fundamental determinants of ion channel function: (1) the number of channels resident in a membrane and (2) the activity of the channel at the membrane. ...Finally, I discuss future goals and challenges for the field to underst …
S-acylation can control the two fundamental determinants of ion channel function: (1) the number of channels resident in a mem …
Structure and mechanogating of the mammalian tactile channel PIEZO2.
Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, Li Y, Lei J, Li X, Xiao B. Wang L, et al. Nature. 2019 Sep;573(7773):225-229. doi: 10.1038/s41586-019-1505-8. Epub 2019 Aug 21. Nature. 2019. PMID: 31435011
PIEZO2 is a mechanosensitive cation channel that has a key role in sensing touch, tactile pain, breathing and blood pressure. ...Together, our studies provide insights into the structure and mechanogating mechanism of Piezo channels....
PIEZO2 is a mechanosensitive cation channel that has a key role in sensing touch, tactile pain, breathing and blood pressure. ...Toge …
104,007 results
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