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Pembrolizumab alone or with chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: Health-related quality-of-life results from KEYNOTE-048.
Oral Oncol. 2022 May;128:105815. doi: 10.1016/j.oraloncology.2022.105815. Epub 2022 Apr 2.
Oral Oncol. 2022.
PMID: 35381576
Free article.
Clinical Trial.
OBJECTIVES: To assess health-related quality of life (HRQoL) with first-line pembrolizumab, pembrolizumab-chemotherapy, or cetuximab-chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) in the phase 3 KEYNOTE-048 trial (NCT02358031). MA …
OBJECTIVES: To assess health-related quality of life (HRQoL) with first-line pembrolizumab, pembrolizumab-chemotherapy, or cetuximab-chemoth …
Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension.
Mantegazza R, Wolfe GI, Muppidi S, Wiendl H, Fujita KP, O'Brien FL, Booth HDE, Howard JF Jr; REGAIN Study Group.
Mantegazza R, et al.
Neurology. 2021 Jan 26;96(4):e610-e618. doi: 10.1212/WNL.0000000000011207. Epub 2020 Nov 23.
Neurology. 2021.
PMID: 33229455
Free PMC article.
Clinical Trial.
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Consistent improvement with eculizumab across muscle groups in myasthenia gravis.
Mantegazza R, O'Brien FL, Yountz M, Howard JF Jr; REGAIN study group.
Mantegazza R, et al.
Ann Clin Transl Neurol. 2020 Aug;7(8):1327-1339. doi: 10.1002/acn3.51121. Epub 2020 Jul 22.
Ann Clin Transl Neurol. 2020.
PMID: 32700461
Free PMC article.
Clinical Trial.
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New insights into H2 activation by intramolecular frustrated Lewis pairs based on aminoboranes: the local electrophilicity index of boron as a suitable indicator to tune the reversibility of the process.
Barrales-Martínez C, Durán R, Jaque P.
Barrales-Martínez C, et al.
Chem Sci. 2023 Oct 3;14(42):11798-11808. doi: 10.1039/d3sc03992g. eCollection 2023 Nov 1.
Chem Sci. 2023.
PMID: 37920343
Free PMC article.
Three different linkers were employed, keeping the C-C nature in the connection between both Lewis centers: -CH(2)-CH(2)-, -CH[double bond, length as m-dash]CH-, and -C(6)H(4)-. The results show that significant differences in the Gibbs free energy of the process are found …
Three different linkers were employed, keeping the C-C nature in the connection between both Lewis centers: -CH(2)-CH(2)-, -CH[double bond, …
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Synthesis of Five Known Brassinosteroid Analogs from Hyodeoxycholic Acid and Their Activities as Plant-Growth Regulators.
Duran MI, González C, Acosta A, Olea AF, Díaz K, Espinoza L.
Duran MI, et al.
Int J Mol Sci. 2017 Mar 8;18(3):516. doi: 10.3390/ijms18030516.
Int J Mol Sci. 2017.
PMID: 28282853
Free PMC article.
The growth-promoting effects of brassinolide (1) and synthesized analogs were evaluated by using the rice lamina inclination assay at concentrations ranging from 1 10(-8)-1 10(-6) M. Our results indicate that in this concentration range the induced bending angle of rice se …
The growth-promoting effects of brassinolide (1) and synthesized analogs were evaluated by using the rice lamina inclination assay at concen …
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