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Page 1
Clinical effectiveness of septoplasty versus medical management for nasal airways obstruction: multicentre, open label, randomised controlled trial.
Carrie S, O'Hara J, Fouweather T, Homer T, Rousseau N, Rooshenas L, Bray A, Stocken DD, Ternent L, Rennie K, Clark E, Waugh N, Steel AJ, Dooley J, Drinnan M, Hamilton D, Lloyd K, Oluboyede Y, Wilson C, Gardiner Q, Kara N, Khwaja S, Leong SC, Maini S, Morrison J, Nix P, Wilson JA, Teare MD. Carrie S, et al. BMJ. 2023 Oct 18;383:e075445. doi: 10.1136/bmj-2023-075445. BMJ. 2023. PMID: 37852641 Free PMC article. Clinical Trial.
RESULTS: Mean SNOT-22 scores at six months were 19.9 (95% confidence interval 17.0 to 22.7) in the septoplasty arm (n=152, intention-to-treat population) and 39.5 (36.1 to 42.9) in the medical management arm (n=155); an estimated 20.0 points lower (better) for participants random …
RESULTS: Mean SNOT-22 scores at six months were 19.9 (95% confidence interval 17.0 to 22.7) in the septoplasty arm (n=152, intention-to-trea …
Socioeconomic, comorbidity, lifestyle, and quality of life comparisons between chronic rhinosinusitis phenotypes.
Philpott C, Ta NH, Hopkins C, Ray J, Ahmed S, Almeyda R, Kara N, Carrie S, Erskine SE, Cathcart R, Sunkaraneni V, Robertson A, Anari S, Kumar BN, Clark A; CRES Group. Philpott C, et al. Laryngoscope. 2021 Oct;131(10):2179-2186. doi: 10.1002/lary.29527. Epub 2021 Mar 26. Laryngoscope. 2021. PMID: 33769590
The key socioeconomic variables did not demonstrate any notable differences, nor did lifestyle variables other than alcohol consumption being higher in those with CRSwNP (P = .032), but the latter was not significant after adjusting for age and sex. Aside from confirmation …
The key socioeconomic variables did not demonstrate any notable differences, nor did lifestyle variables other than alcohol consumption bein …
ACTIVATION (PercutAneous Coronary inTervention prIor to transcatheter aortic VAlve implantaTION): A Randomized Clinical Trial.
Patterson T, Clayton T, Dodd M, Khawaja Z, Morice MC, Wilson K, Kim WK, Meneveau N, Hambrecht R, Byrne J, Carrié D, Fraser D, Roberts DH, Doshi SN, Zaman A, Banning AP, Eltchaninoff H, Le Breton H, Smith D, Cox I, Frank D, Gershlick A, de Belder M, Thomas M, Hildick-Smith D, Prendergast B, Redwood S; ACTIVATION Trial Investigators. Patterson T, et al. JACC Cardiovasc Interv. 2021 Sep 27;14(18):1965-1974. doi: 10.1016/j.jcin.2021.06.041. JACC Cardiovasc Interv. 2021. PMID: 34556269 Free article. Clinical Trial.
The requirement for noninferiority was not met (difference: -2.5%; 1-sided upper 95% confidence limit: 8.5%; 1-sided noninferiority test P = 0.067). On analysis of the as-treated population, the difference was -3.7% (1-sided upper 95% confidence limit: 7.5%; P = 0.0 …
The requirement for noninferiority was not met (difference: -2.5%; 1-sided upper 95% confidence limit: 8.5%; 1-sided noninferiority test …
Quality of life benefit after endoscopic frontal sinus surgery.
ElBadawey MR, Alwaa A, ElTaher M, Carrie S. ElBadawey MR, et al. Am J Rhinol Allergy. 2014 Sep-Oct;28(5):428-32. doi: 10.2500/ajra.2014.28.4063. Am J Rhinol Allergy. 2014. PMID: 25198031
The SNOT-22 preoperative score was +59.8 and this significantly improved to +35.2 (p = 0.017). CONCLUSION: Our study is the first report of QOL benefit after all three frontal sinus procedures using the validated GBI, showing benefit in all aspects of health domains. ...
The SNOT-22 preoperative score was +59.8 and this significantly improved to +35.2 (p = 0.017). CONCLUSION: Our study is the first rep …
Current use of baseline medical treatment in chronic rhinosinusitis: Data from the National Chronic Rhinosinusitis Epidemiology Study (CRES).
Philpott C, Erskine S, Smith R, Hopkins C, Kara N, Farboud A, Salam M, Robertson A, Almeyda R, Kumar BN, Anari S, Ray J, Cathcart R, Carrie S, Ahmed S, Khalil H, Clark A, Thomas M; CRES group. Philpott C, et al. Clin Otolaryngol. 2018 Apr;43(2):509-524. doi: 10.1111/coa.13012. Epub 2017 Dec 11. Clin Otolaryngol. 2018. PMID: 29055085
Bronchodilators and inhaled corticosteroids use was significantly higher in CRSwNPs participants (P < .0001). Antidepressant use was significantly higher in CRSsNPs (14% vs 7%, P < .0002). ...

Bronchodilators and inhaled corticosteroids use was significantly higher in CRSwNPs participants (P < .0001). Antidepressant use w

Pressure-Controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction: The PiCSO-AMI-I Trial.
De Maria GL, Greenwood JP, Zaman AG, Carrié D, Coste P, Valgimigli M, Behan M, Berry C, Erglis A, Panoulas VF, Van Belle E, Juhl Terkelsen C, Hunziker Munsch L, Jain AK, Lassen JF, Palmer N, Stone GW, Banning AP. De Maria GL, et al. Circ Cardiovasc Interv. 2024 Apr;17(4):e013675. doi: 10.1161/CIRCINTERVENTIONS.123.013675. Epub 2024 Apr 16. Circ Cardiovasc Interv. 2024. PMID: 38626079 Clinical Trial.
No differences were observed in IS at 5 days (27.2%12.4% versus 28.3%11.45%; P=0.59) and 6 months (19.2%10.1% versus 18.8%7.7%; P=0.83), nor were differences between PiCSO-treated and control patients noted in terms of the occurrence of microvascular obstruction (67 …
No differences were observed in IS at 5 days (27.2%12.4% versus 28.3%11.45%; P=0.59) and 6 months (19.2%10.1% versus 18.8%7.7%; P
Quality of life assessment after non-laser endonasal dacryocystorhinostomy.
Ho A, Sachidananda R, Carrie S, Neoh C. Ho A, et al. Clin Otolaryngol. 2006 Oct;31(5):399-403. doi: 10.1111/j.1749-4486.2006.01278.x. Clin Otolaryngol. 2006. PMID: 17014449

Mean total GBI scores were +34 for successful non-laser endonasal dacryocystorhinostomy and -19 for failed non-laser endonasal dacryocystorhinostomy (Mann-Whitney z = 3.8, P < 0.001). CONCLUSION: Successful non-laser endonasal dacryocystorhinostomy does confer significa

Mean total GBI scores were +34 for successful non-laser endonasal dacryocystorhinostomy and -19 for failed non-laser endonasal dacryocystorh …
MUC5B secretion is up-regulated in sinusitis compared with controls.
Viswanathan H, Brownlee IA, Pearson JP, Carrie S. Viswanathan H, et al. Am J Rhinol. 2006 Sep-Oct;20(5):554-7. doi: 10.2500/ajr.2006.20.2935. Am J Rhinol. 2006. PMID: 17063754
CONCLUSION: MUC5B secretion is significantly up-regulated in CRS compared with control subjects (p = 0.04). Correlation between viscosity and mucin content was lost in CRS. ...
CONCLUSION: MUC5B secretion is significantly up-regulated in CRS compared with control subjects (p = 0.04). Correlation between visco …
Effectiveness of septoplasty compared to medical management in adults with obstruction associated with a deviated nasal septum: the NAIROS RCT.
Carrie S, Fouweather T, Homer T, O'Hara J, Rousseau N, Rooshenas L, Bray A, Stocken DD, Ternent L, Rennie K, Clark E, Waugh N, Steel AJ, Dooley J, Drinnan M, Hamilton D, Lloyd K, Oluboyede Y, Wilson C, Gardiner Q, Kara N, Khwaja S, Leong SC, Maini S, Morrison J, Nix P, Wilson JA, Teare MD. Carrie S, et al. Health Technol Assess. 2024 Mar;28(10):1-213. doi: 10.3310/MVFR4028. Health Technol Assess. 2024. PMID: 38477237 Free PMC article. Clinical Trial.
The 6-month mean Sino-nasal Outcome Test-22 items scores were -20.0 points lower (better) for participants randomised to septoplasty than for those randomised to medical management [the score for the septoplasty arm was 19.9 and the score for the medical management arm was 39.5 ( …
The 6-month mean Sino-nasal Outcome Test-22 items scores were -20.0 points lower (better) for participants randomised to septoplasty than fo …
The burden of revision sinonasal surgery in the UK-data from the Chronic Rhinosinusitis Epidemiology Study (CRES): a cross-sectional study.
Philpott C, Hopkins C, Erskine S, Kumar N, Robertson A, Farboud A, Ahmed S, Anari S, Cathcart R, Khalil H, Jervis P, Carrie S, Kara N, Prinsley P, Almeyda R, Mansell N, Sunkaraneni S, Salam M, Ray J, Panesaar J, Hobson J, Clark A, Morris S. Philpott C, et al. BMJ Open. 2015 Apr 29;5(4):e006680. doi: 10.1136/bmjopen-2014-006680. BMJ Open. 2015. PMID: 25926143 Free PMC article.
For comparison, surgical rates in patients with CRSsNPs were significantly lower; 13% of cases specifically reported ESS, and of those only 30% reported multiple procedures (chi(2) p<0.001). CONCLUSIONS: This study demonstrated that there is a high burden of both primar …
For comparison, surgical rates in patients with CRSsNPs were significantly lower; 13% of cases specifically reported ESS, and of those only …