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Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation.
Bowen EE, Hurcombe JA, Barrington F, Keir LS, Farmer LK, Wherlock MD, Ortiz-Sandoval CG, Bruno V, Bohorquez-Hernandez A, Diatlov D, Rostam-Shirazi N, Wells S, Stewart M, Teboul L, Lay AC, Butler MJ, Pope RJP, Larkai EMS, Morgan BP, Moppett J, Satchell SC, Welsh GI, Walker PD, Licht C, Saleem MA, Coward RJM. Bowen EE, et al. Among authors: ortiz sandoval cg. Med. 2023 Nov 10;4(11):761-777.e8. doi: 10.1016/j.medj.2023.09.002. Epub 2023 Oct 19. Med. 2023. PMID: 37863058 Free article.
Shiga Toxin 2a Induces NETosis via NOX-Dependent Pathway.
Feitz WJC, Suntharalingham S, Khan M, Ortiz-Sandoval CG, Palaniyar N, van den Heuvel LP, van de Kar NCAJ, Licht C. Feitz WJC, et al. Among authors: ortiz sandoval cg. Biomedicines. 2021 Dec 1;9(12):1807. doi: 10.3390/biomedicines9121807. Biomedicines. 2021. PMID: 34944623 Free PMC article.
The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury.
Teoh CW, Riedl Khursigara M, Ortiz-Sandoval CG, Park JW, Li J, Bohorquez-Hernandez A, Bruno V, Bowen EE, Freeman SA, Robinson LA, Licht C. Teoh CW, et al. Among authors: ortiz sandoval cg. Front Med (Lausanne). 2023 Feb 13;10:891513. doi: 10.3389/fmed.2023.891513. eCollection 2023. Front Med (Lausanne). 2023. PMID: 36860338 Free PMC article.