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Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling.
Estupiñán Ó, Rey V, Tornín J, Murillo D, Gallego B, Huergo C, Blanco-Lorenzo V, Victoria González M, Rodríguez A, Moris F, González J, Ayllón V, Ramos-Mejía V, Bigas A, Rodríguez R. Estupiñán Ó, et al. Among authors: huergo c. Biomed Pharmacother. 2023 Jun;162:114627. doi: 10.1016/j.biopha.2023.114627. Epub 2023 Apr 3. Biomed Pharmacother. 2023. PMID: 37018985 Free article.
Proof of concept for the use of trained sniffer dogs to detect osteosarcoma.
Ortal A, Rodríguez A, Solis-Hernández MP, de Prado M, Rey V, Tornín J, Estupiñán Ó, Gallego B, Murillo D, Huergo C, García-Llano JL, Costilla S, Rodríguez R. Ortal A, et al. Among authors: huergo c. Sci Rep. 2022 Apr 28;12(1):6911. doi: 10.1038/s41598-022-11013-1. Sci Rep. 2022. PMID: 35484295 Free PMC article.
A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma.
Rey V, Tornín J, Alba-Linares JJ, Robledo C, Murillo D, Rodríguez A, Gallego B, Huergo C, Viera C, Braña A, Astudillo A, Heymann D, Szuhai K, Bovée JVMG, Fernández AF, Fraga MF, Alonso J, Rodríguez R. Rey V, et al. Among authors: huergo c. EBioMedicine. 2024 Apr;102:105090. doi: 10.1016/j.ebiom.2024.105090. Epub 2024 Mar 27. EBioMedicine. 2024. PMID: 38547578 Free PMC article.