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Dosing strategies for de novo once-daily extended release tacrolimus in kidney transplant recipients based on CYP3A5 genotype.
Diamond A, Karhadkar S, Chavin K, Constantinescu S, Lau KN, Perez-Leal O, Mohrien K, Sifontis N, Di Carlo A. Diamond A, et al. Among authors: di carlo a. World J Transplant. 2023 Dec 18;13(6):368-378. doi: 10.5500/wjt.v13.i6.368. World J Transplant. 2023. PMID: 38174147 Free PMC article.
LCPT dose was adjusted to maintain tacrolimus trough concentrations of 8-10 ng/mL. Pharmacogenetic analysis of CYP3A5 genotype was performed at study conclusion. ...CYP3A5 extensive metabolizers experienced lower mean tacrolimus trough concentrations throughout the study p …
LCPT dose was adjusted to maintain tacrolimus trough concentrations of 8-10 ng/mL. Pharmacogenetic analysis of CYP3A5 genotype was pe …