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Page 1
Exogenous Iron Increases Fasciocidal Activity and Hepatocellular Toxicity of the Synthetic Endoperoxides OZ78 and MT04.
Int J Mol Sci. 2019 Oct 1;20(19):4880. doi: 10.3390/ijms20194880.
Int J Mol Sci. 2019.
PMID: 31581457
Free PMC article.
Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni.
Kirchhofer C, Vargas M, Braissant O, Dong Y, Wang X, Vennerstrom JL, Keiser J.
Kirchhofer C, et al.
Acta Trop. 2011 Apr;118(1):56-62. doi: 10.1016/j.actatropica.2011.02.003. Epub 2011 Feb 21.
Acta Trop. 2011.
PMID: 21316331
Free PMC article.
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Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate.
Kirchhofer C, Keiser J, Huwyler J.
Kirchhofer C, et al.
J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15;878(28):2770-4. doi: 10.1016/j.jchromb.2010.08.020. Epub 2010 Aug 21.
J Chromatogr B Analyt Technol Biomed Life Sci. 2010.
PMID: 20829125
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Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica.
Keiser J, Manneck T, Kirchhofer C, Braissant O.
Keiser J, et al. Among authors: kirchhofer c.
Exp Parasitol. 2013 Mar;133(3):265-8. doi: 10.1016/j.exppara.2012.11.020. Epub 2012 Dec 1.
Exp Parasitol. 2013.
PMID: 23206957
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Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies.
Kirchhofer C, Vargas M, Huwyler J, Keiser J.
Kirchhofer C, et al.
Int J Parasitol Drugs Drug Resist. 2012 Apr 14;2:121-5. doi: 10.1016/j.ijpddr.2012.03.003. eCollection 2012 Dec.
Int J Parasitol Drugs Drug Resist. 2012.
PMID: 24533273
Free PMC article.
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Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep.
Keiser J, Kirchhofer C, Haschke M, Huwyler J, Dong Y, Vennerstrom JL, Vanhoff K, Kaminsky R, Malikides N.
Keiser J, et al. Among authors: kirchhofer c.
Vet Parasitol. 2010 Oct 29;173(3-4):228-35. doi: 10.1016/j.vetpar.2010.06.031. Epub 2010 Jun 25.
Vet Parasitol. 2010.
PMID: 20674178
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