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A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway.
Goupil E, Tassy D, Bourguet C, Quiniou C, Wisehart V, Pétrin D, Le Gouill C, Devost D, Zingg HH, Bouvier M, Saragovi HU, Chemtob S, Lubell WD, Claing A, Hébert TE, Laporte SA. Goupil E, et al. Among authors: bourguet c. J Biol Chem. 2010 Aug 13;285(33):25624-36. doi: 10.1074/jbc.M110.115196. Epub 2010 Jun 15. J Biol Chem. 2010. PMID: 20551320 Free PMC article.
Portraits of the pioneers of the American Peptide Society.
Bourguet CB, Dörr A, Godina T, Proulx C, Fridkin G, Jamieson A, Sabatino D, Kassem T, Boutard N, Arsenault J, Ronga L, Brouillette Y, Bednarek M, Tolles JC, Lubell WD. Bourguet CB, et al. Adv Exp Med Biol. 2009;611:xlix-lxix. Adv Exp Med Biol. 2009. PMID: 19400064 No abstract available.