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2021 4
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Page 1
Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas.
Khan A, Gamble LD, Upton DH, Ung C, Yu DMT, Ehteda A, Pandher R, Mayoh C, Hébert S, Jabado N, Kleinman CL, Burns MR, Norris MD, Haber M, Tsoli M, Ziegler DS. Khan A, et al. Among authors: ung c. Nat Commun. 2021 Feb 12;12(1):971. doi: 10.1038/s41467-021-20896-z. Nat Commun. 2021. PMID: 33579942 Free PMC article.
In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer.
Lau LMS, Mayoh C, Xie J, Barahona P, MacKenzie KL, Wong M, Kamili A, Tsoli M, Failes TW, Kumar A, Mould EVA, Gifford A, Chow SO, Pinese M, Fletcher JI, Arndt GM, Khuong-Quang DA, Wadham C, Batey D, Eden G, Trebilcock P, Joshi S, Alfred S, Gopalakrishnan A, Khan A, Grebert Wade D, Strong PA, Manouvrier E, Morgan LT, Span M, Lim JY, Cadiz R, Ung C, Thomas DM, Tucker KM, Warby M, McCowage GB, Dalla-Pozza L, Byrne JA, Saletta F, Fellowes A, Fox SB, Norris MD, Tyrrell V, Trahair TN, Lock RB, Cowley MJ, Ekert PG, Haber M, Ziegler DS, Marshall GM. Lau LMS, et al. Among authors: ung c. EMBO Mol Med. 2022 Apr 7;14(4):e14608. doi: 10.15252/emmm.202114608. Epub 2021 Dec 20. EMBO Mol Med. 2022. PMID: 34927798 Free PMC article.
Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG.
Ehteda A, Simon S, Franshaw L, Giorgi FM, Liu J, Joshi S, Rouaen JRC, Pang CNI, Pandher R, Mayoh C, Tang Y, Khan A, Ung C, Tolhurst O, Kankean A, Hayden E, Lehmann R, Shen S, Gopalakrishnan A, Trebilcock P, Gurova K, Gudkov AV, Norris MD, Haber M, Vittorio O, Tsoli M, Ziegler DS. Ehteda A, et al. Among authors: ung c. Cell Rep. 2021 Apr 13;35(2):108994. doi: 10.1016/j.celrep.2021.108994. Cell Rep. 2021. PMID: 33852836 Free article.