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Page 1
Tumor-targeted delivery of a STING agonist improvescancer immunotherapy.
Wu YT, Fang Y, Wei Q, Shi H, Tan H, Deng Y, Zeng Z, Qiu J, Chen C, Sun L, Chen ZJ. Wu YT, et al. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2214278119. doi: 10.1073/pnas.2214278119. Epub 2022 Nov 29. Proc Natl Acad Sci U S A. 2022. PMID: 36442099 Free PMC article.
C,C- and C,N-Chelated Organocopper Compounds.
Liu L, Chen H, Yang Z, Wei J, Xi Z. Liu L, et al. Molecules. 2021 Sep 25;26(19):5806. doi: 10.3390/molecules26195806. Molecules. 2021. PMID: 34641351 Free PMC article. Review.
Meanwhile, the structure-function relationship of organocopper compounds could advance the rational design and development of new Cu-based reactions and organocopper reagents. Compared to the mono-carbonic ligand, the C,N- and C,C-bidentate ligands better stabilize …
Meanwhile, the structure-function relationship of organocopper compounds could advance the rational design and development of new Cu-based r …
RACK1 promotes cancer progression by increasing the M2/M1 macrophage ratio via the NF-κB pathway in oral squamous cell carcinoma.
Dan H, Liu S, Liu J, Liu D, Yin F, Wei Z, Wang J, Zhou Y, Jiang L, Ji N, Zeng X, Li J, Chen Q. Dan H, et al. Mol Oncol. 2020 Apr;14(4):795-807. doi: 10.1002/1878-0261.12644. Epub 2020 Feb 20. Mol Oncol. 2020. PMID: 31997535 Free PMC article.
A mechanistic study revealed that the expression and secretion of C-C motif chemokine 2 (CCL2), C-C motif chemokine 5 (CCL5), interleukin-6 (IL-6), and interleukin-1 (IL-1) are closely related to RACK1 expression. ...
A mechanistic study revealed that the expression and secretion of C-C motif chemokine 2 (CCL2), C-C motif chemok …
Tumor-associated macrophage-derived chemokine CCL5 facilitates the progression and immunosuppressive tumor microenvironment of clear cell renal cell carcinoma.
Xu W, Wu Y, Liu W, Anwaier A, Tian X, Su J, Huang H, Wei G, Qu Y, Zhang H, Ye D. Xu W, et al. Int J Biol Sci. 2022 Jul 18;18(13):4884-4900. doi: 10.7150/ijbs.74647. eCollection 2022. Int J Biol Sci. 2022. PMID: 35982911 Free PMC article.
Methods: We comprehensively evaluated the prognostic implications, biological behaviors, and immunogenomics features of the C-C Motif Chemokine Ligand 5 (CCL5) expression and CCL5(+) TME in vitro and in 932 real-world ccRCC patients from testing and public validatio …
Methods: We comprehensively evaluated the prognostic implications, biological behaviors, and immunogenomics features of the C-C …
Progress in Stereoselective Construction of C-C Bonds Enabled by Aldolases and Hydroxynitrile Lyases.
Liu M, Wei D, Wen Z, Wang JB. Liu M, et al. Front Bioeng Biotechnol. 2021 Apr 21;9:653682. doi: 10.3389/fbioe.2021.653682. eCollection 2021. Front Bioeng Biotechnol. 2021. PMID: 33968915 Free PMC article. Review.
The creation of C-C bonds is an effective strategy for constructing complex compounds from simple synthetic blocks. Although many methods have been developed for C-C bond construction, the stereoselective creation of new C-C bonds remains …
The creation of C-C bonds is an effective strategy for constructing complex compounds from simple synthetic blocks. Although m …
Cu(II)-Mediated aerobic oxidative synthesis of sulfonated chromeno[4,3-c]pyrazol-4(2H)-ones.
Zhou Q, Yu HY, Zhou Y, Wei JR, Wang L. Zhou Q, et al. Org Biomol Chem. 2022 Jul 20;20(28):5575-5581. doi: 10.1039/d2ob00639a. Org Biomol Chem. 2022. PMID: 35792135
Herein, starting with propiolates and sulfonyl hydrazides, we developed a concise and facile synthesis of 2-sulfonylated chromeno [4,3-c]pyrazol-4(2H)-ones or 2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-ones via Cu(II)-promoted oxidative cascade C-C/C-N bond for …
Herein, starting with propiolates and sulfonyl hydrazides, we developed a concise and facile synthesis of 2-sulfonylated chromeno [4,3-c]pyr …
Discovery and mechanism of intestinal bacteria in enzymatic cleavage of C-C glycosidic bonds.
Wei B, Wang YK, Qiu WH, Wang SJ, Wu YH, Xu XW, Wang H. Wei B, et al. Appl Microbiol Biotechnol. 2020 Mar;104(5):1883-1890. doi: 10.1007/s00253-019-10333-z. Epub 2020 Jan 13. Appl Microbiol Biotechnol. 2020. PMID: 31932892 Review.
Interestingly, C-glycosides could be cleaved by several intestinal bacteria, but whether the enzymatic cleavage of C-C glycosidic bond is reduction or hydrolysis has been controversial; furthermore, whether existence of a "C-glycosidase" directly catalyzing the clea …
Interestingly, C-glycosides could be cleaved by several intestinal bacteria, but whether the enzymatic cleavage of C-C glycosi …
Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C-C Motif Chemokine Ligand 2-Mediated Angiocrine Signaling.
Gao J, Wei B, Liu M, Hirsova P, Sehrawat TS, Cao S, Hu X, Xue F, Yaqoob U, Kang N, Cui H, Pomerantz WCK, Kostallari E, Shah VH. Gao J, et al. Hepatology. 2021 Jun;73(6):2468-2483. doi: 10.1002/hep.31617. Epub 2021 Apr 19. Hepatology. 2021. PMID: 33159815 Free PMC article.
Mice with LSEC-specific p300 deletion (p300(LSECdelta/delta) ) or C-C motif chemokine ligand 2 (Ccl2) deficiency, nuclear factor kappa B (NFkappaB)-p50 knockout mice, and bromodomain containing 4 (BRD4) inhibitors in wild-type mice were used to investigate mechanism …
Mice with LSEC-specific p300 deletion (p300(LSECdelta/delta) ) or C-C motif chemokine ligand 2 (Ccl2) deficiency, nuclear fact …
Single-photon ionization induced C-C or C-N bond formation in pyrrole clusters.
Wei C, Chen X, Wang Y, Li Y, Gao J, Xie M, Hu Y. Wei C, et al. Phys Chem Chem Phys. 2023 Apr 26;25(16):11368-11374. doi: 10.1039/d3cp00028a. Phys Chem Chem Phys. 2023. PMID: 37013866
With 118 nm light ionization of the (py)(2), we elucidate that the two py are more inclined to be stabilized by a newly formed C-C or C-N covalent bond, besides the pi-stacked parallel structure of (py)(2)(+). The (py)(3)(+) with a C-C or C-N covalent …
With 118 nm light ionization of the (py)(2), we elucidate that the two py are more inclined to be stabilized by a newly formed C-C …
Catalytic Multicomponent Synthesis of C-Acyl Glycosides by Consecutive Cross-Electrophile Couplings.
Jiang Y, Yang K, Wei Y, Wang Q, Li SJ, Lan Y, Koh MJ. Jiang Y, et al. Angew Chem Int Ed Engl. 2022 Nov 14;61(46):e202211043. doi: 10.1002/anie.202211043. Epub 2022 Oct 17. Angew Chem Int Ed Engl. 2022. PMID: 36165541
Conventional cross-coupling strategies to secure these molecules often relied on two-component manifolds in which a glycosyl precursor is coupled with an acyl donor (pre-synthesized or generated in situ) under transition metal or dual catalysis to forge a C-C bond. …
Conventional cross-coupling strategies to secure these molecules often relied on two-component manifolds in which a glycosyl precursor is co …
604 results