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Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers.
Khan W, Wang YH, Chaurasiya ND, Nanayakkara ND, Herath HB, Harrison KA, Dale G, Stanford DA, Dahl EP, McChesney JD, Gul W, ElSohly MA, Khan SI, Fasinu PS, Khan IA, Tekwani BL, Walker LA. Khan W, et al. Among authors: dahl ep. Drug Metab Pharmacokinet. 2022 Aug;45:100463. doi: 10.1016/j.dmpk.2022.100463. Epub 2022 May 2. Drug Metab Pharmacokinet. 2022. PMID: 35709685 Free PMC article.
Relative PQ exposure was higher with SPQ as compared to RPQ. PQ maximum plasma concentration (C(max)) and area under the plasma concentration-time curve were higher for SPQ, while the apparent volume of distribution and total body clearance were higher for RPQ. Metabolism …
Relative PQ exposure was higher with SPQ as compared to RPQ. PQ maximum plasma concentration (C(max)) and area under the plasma conce …