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A critical review of literature regarding the effectiveness of physical therapy management of hip fracture in elderly persons.
Toussant EM, Kohia M. Toussant EM, et al. J Gerontol A Biol Sci Med Sci. 2005 Oct;60(10):1285-91. doi: 10.1093/gerona/60.10.1285. J Gerontol A Biol Sci Med Sci. 2005. PMID: 16282561 Review.
Fifteen studies met the criteria and were then categorized according to Sackett's levels of evidence. Six studies were graded at level I, six at level II, and three at level V, with level I having the highest level of evidence. From the levels of evidence, one grade A, thr …
Fifteen studies met the criteria and were then categorized according to Sackett's levels of evidence. Six studies were graded at leve …
Localization of the colchicine-binding site of tubulin.
Uppuluri S, Knipling L, Sackett DL, Wolff J. Uppuluri S, et al. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11598-602. doi: 10.1073/pnas.90.24.11598. Proc Natl Acad Sci U S A. 1993. PMID: 8265596 Free PMC article.
To identify which peptide carried the label, limited hydrolysis of beta-tubulin was done with trypsin; this procedure yielded a labeled 16-kDa N-terminal peptide and a 35-kDa C-terminal peptide, as identified by antibodies. Isolation of these peptides and extensive digesti …
To identify which peptide carried the label, limited hydrolysis of beta-tubulin was done with trypsin; this procedure yielded a labeled 16-k …
Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration.
Rostovtseva TK, Sheldon KL, Hassanzadeh E, Monge C, Saks V, Bezrukov SM, Sackett DL. Rostovtseva TK, et al. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18746-51. doi: 10.1073/pnas.0806303105. Epub 2008 Nov 24. Proc Natl Acad Sci U S A. 2008. PMID: 19033201 Free PMC article.
Our findings suggest a previously unknown mechanism of regulation of mitochondrial energetics, governed by VDAC and tubulin at the mitochondria-cytosol interface. This tubulin-VDAC interaction requires tubulin anionic C-terminal tail (CTT) peptides. The significance of thi …
Our findings suggest a previously unknown mechanism of regulation of mitochondrial energetics, governed by VDAC and tubulin at the mitochond …