Macrophage CD5L is a target for cancer immunotherapy.
Sanchez-Moral L, Paul T, Martori C, Font-Díaz J, Sanjurjo L, Aran G, Téllez É, Blanco J, Carrillo J, Ito M, Tuttolomondo M, Ditzel HJ, Fumagalli C, Tapia G, Sidorova J, Masnou H, Fernández-Sanmartín MA, Lozano JJ, Vilaplana C, Rodriguez-Cortés A, Armengol C, Valledor AF, Kremer L, Sarrias MR.
Sanchez-Moral L, et al.
EBioMedicine. 2023 May;91:104555. doi: 10.1016/j.ebiom.2023.104555. Epub 2023 Apr 11.
EBioMedicine. 2023.
PMID: 37054630
Free PMC article.
Accordingly, high TAM expression of CD5L in PAC was associated with poor patient outcome (Log-rank (Mantel-Cox) test p = 0.02). We raised a new anti-CD5L mAb that blocked the immunosuppressive phenotype of macrophages in vitro. ...INTERPRETATION: CD5L protein plays a key f …
Accordingly, high TAM expression of CD5L in PAC was associated with poor patient outcome (Log-rank (Mantel-Cox) test p = 0.02). We ra …