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1998 1
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2016 3
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2019 3
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37 results

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Page 1
Resistance to Second-Generation HIV-1 Maturation Inhibitors.
Urano E, Timilsina U, Kaplan JA, Ablan S, Ghimire D, Pham P, Kuruppu N, Mandt R, Durell SR, Nitz TJ, Martin DE, Wild CT, Gaur R, Freed EO. Urano E, et al. J Virol. 2019 Mar 5;93(6):e02017-18. doi: 10.1128/JVI.02017-18. Print 2019 Mar 15. J Virol. 2019. PMID: 30567982 Free PMC article.
Single amino acid polymorphisms in the SP1 region of Gag and the C terminus of CA reduced HIV-1 susceptibility to BVM, leading to the discontinuation of BVM's clinical development. ...Here, we demonstrate that viral clones bearing BVM resistance mutations near the C …
Single amino acid polymorphisms in the SP1 region of Gag and the C terminus of CA reduced HIV-1 susceptibility to BVM, leading to the …
Production of soluble Neprilysin by endothelial cells.
Kuruppu S, Rajapakse NW, Minond D, Smith AI. Kuruppu S, et al. Biochem Biophys Res Commun. 2014 Apr 4;446(2):423-7. doi: 10.1016/j.bbrc.2014.01.158. Epub 2014 Feb 2. Biochem Biophys Res Commun. 2014. PMID: 24495806
Treatment of cells with TPI2155-14 (15 muM) and TPI2155-17 (4.3 muM) resulted in a significant decrease in NEP activity in media (62.371.43 and 38.304.70, respectively as a % of control; P<0.0001), implicating a possible role for ADAM-17 in NEP release. However, centrifuging m …
Treatment of cells with TPI2155-14 (15 muM) and TPI2155-17 (4.3 muM) resulted in a significant decrease in NEP activity in media (62.371.43 …
Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4.
Kil KE, Poutiainen P, Zhang Z, Zhu A, Kuruppu D, Prabhakar S, Choi JK, Tannous BA, Brownell AL. Kil KE, et al. Bioorg Med Chem Lett. 2016 Jan 1;26(1):133-9. doi: 10.1016/j.bmcl.2015.11.015. Epub 2015 Nov 10. Bioorg Med Chem Lett. 2016. PMID: 26602273 Free PMC article.
Compound 11 also showed enhanced metabolic stability and good selectivity to other mGluRs. [(11)C]11 and [(11)C]14 were radiolabeled using the [(11)C]methylation of the thiophenol precursors 20a and 20c with [(11)C]CH3I in 19.0% and 34.8% radiochemical …
Compound 11 also showed enhanced metabolic stability and good selectivity to other mGluRs. [(11)C]11 and [(11)C]14 were radiol …
Protein Kinase C recognition sites in the cytoplasmic domain of Endothelin Converting Enzyme-1c.
Kuruppu S, Tochon-Danguy N, Smith AI. Kuruppu S, et al. Biochem Biophys Res Commun. 2012 Oct 26;427(3):606-10. doi: 10.1016/j.bbrc.2012.09.105. Epub 2012 Sep 27. Biochem Biophys Res Commun. 2012. PMID: 23022525
Endothelin Converting Enzyme-1 (ECE-1) is essential for the production of the potent vasoconstrictor Endothelin-1 (ET-1). The activation of Protein Kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) can increase ECE-1 phosphorylation, which in turn promotes ECE-1c tra …
Endothelin Converting Enzyme-1 (ECE-1) is essential for the production of the potent vasoconstrictor Endothelin-1 (ET-1). The activation of …
Genetic determinants of sporadic breast cancer in Sri Lankan women.
Sirisena ND, Adeyemo A, Kuruppu AI, Neththikumara N, Samaranayake N, Dissanayake VHW. Sirisena ND, et al. BMC Cancer. 2018 Feb 13;18(1):180. doi: 10.1186/s12885-018-4112-4. BMC Cancer. 2018. PMID: 29433565 Free PMC article.
The CTC haplotype defined by the SNPs rs3218552|rs3218550|rs3218536 on chromosome 7 (P = 0.0088) and the CA haplotype defined by the SNPs rs1049620|rs6917 on chromosome 17 (P = 0.0067) were significantly associated with increased risk of breast cancer. The rs1801516 A allele and …
The CTC haplotype defined by the SNPs rs3218552|rs3218550|rs3218536 on chromosome 7 (P = 0.0088) and the CA haplotype defined by the SNPs rs …
Role of Protein Kinase C in Endothelin Converting Enzyme-1 trafficking and shedding from endothelial cells.
Kuruppu S, Tochon-Danguy N, Smith AI. Kuruppu S, et al. Biochem Biophys Res Commun. 2010 Jul 23;398(2):173-7. doi: 10.1016/j.bbrc.2010.06.045. Epub 2010 Jun 15. Biochem Biophys Res Commun. 2010. PMID: 20558134
This study aimed to determine the consequences of Protein Kinase C (PKC) mediated Endothelin Converting Enzyme-1 (ECE-1) phosphorylation and its relationship to ECE-1 expression and shedding. ...
This study aimed to determine the consequences of Protein Kinase C (PKC) mediated Endothelin Converting Enzyme-1 (ECE-1) phosphorylat …
First measurement of neutrino oscillation parameters using neutrinos and antineutrinos by NOvA.
Acero MA, Adamson P, Aliaga L, Alion T, Allakhverdian V, Altakarli S, Anfimov N, Antoshkin A, Aurisano A, Back A, Backhouse C, Baird M, Balashov N, Baldi P, Bambah BA, Bashar S, Bays K, Bending S, Bernstein R, Bhatnagar V, Bhuyan B, Bian J, Blackburn T, Blair J, Booth AC, Bour P, Bromberg C, Buchanan N, Butkevich A, Calvez S, Campbell M, Carroll TJ, Catano-Mur E, Cedeno A, Childress S, Choudhary BC, Chowdhury B, Coan TE, Colo M, Cooper J, Corwin L, Cremonesi L, Davies GS, Derwent PF, Ding P, Djurcic Z, Doyle D, Dukes EC, Duyang H, Edayath S, Ehrlich R, Elkins M, Feldman GJ, Filip P, Flanagan W, Frank MJ, Gallagher HR, Gandrajula R, Gao F, Germani S, Giri A, Gomes RA, Goodman MC, Grichine V, Groh M, Group R, Guo B, Habig A, Hakl F, Hartnell J, Hatcher R, Hatzikoutelis A, Heller K, Hewes J, Himmel A, Holin A, Howard B, Huang J, Hylen J, Jediny F, Johnson C, Judah M, Kakorin I, Kalra D, Kaplan DM, Keloth R, Klimov O, Koerner LW, Kolupaeva L, Kotelnikov S, Kourbanis I, Kreymer A, Kulenberg C, Kumar A, Kuruppu CD, Kus V, Lackey T, Lang K, Lin S, Lokajicek M, Lozier J, Luchuk S, Maan K, Magill S, Mann WA, Marshak ML, Martinez-Casales M, Matveev V, Méndez DP, Messier MD, Meyer H, Miao T,… See abstract for full author list ➔ Acero MA, et al. Phys Rev Lett. 2019 Oct 11;123(15):151803. doi: 10.1103/PhysRevLett.123.151803. Phys Rev Lett. 2019. PMID: 31702305
This new antineutrino data are combined with neutrino data to measure the parameters |deltam_{32}^{2}|=2.48_{-0.06}^{+0.11}10^{-3} eV^{2}/c^{4} and sin^{2}teta_{23} in the ranges from (0.53-0.60) and (0.45-0.48) in the normal neutrino mass hierarchy. ...
This new antineutrino data are combined with neutrino data to measure the parameters |deltam_{32}^{2}|=2.48_{-0.06}^{+0.11}10^{-3} eV^{2}/ …
Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.
Abud AA, Abi B, Acciarri R, Acero MA, Adames MR, Adamov G, Adamowski M, Adams D, Adinolfi M, Aduszkiewicz A, Aguilar J, Ahmad Z, Ahmed J, Aimard B, Ali-Mohammadzadeh B, Alion T, Allison K, Monsalve SA, AlRashed M, Alt C, Alton A, Alvarez R, Amedo P, Anderson J, Andreopoulos C, Andreotti M, Andrews M, Andrianala F, Andringa S, Anfimov N, Ankowski A, Antoniassi M, Antonova M, Antoshkin A, Antusch S, Aranda-Fernandez A, Arellano L, Arnold LO, Arroyave MA, Asaadi J, Asquith L, Aurisano A, Aushev V, Autiero D, Lara VA, Ayala-Torres M, Azfar F, Back A, Back H, Back JJ, Backhouse C, Bagaturia I, Bagby L, Balashov N, Balasubramanian S, Baldi P, Baller B, Bambah B, Barao F, Barenboim G, Alzas PB, Barker G, Barkhouse W, Barnes C, Barr G, Monarca JB, Barros A, Barros N, Barrow JL, Basharina-Freshville A, Bashyal A, Basque V, Batchelor C, Chagas EBD, Battat JBR, Battisti F, Bay F, Bazetto MCQ, Alba JLLB, Beacom JF, Bechetoille E, Behera B, Beigbeder C, Bellantoni L, Bellettini G, Bellini V, Beltramello O, Benekos N, Montiel CB, Neves FB, Berger J, Berkman S, Bernardini P, Berner RM, Bersani A, Bertolucci S, Betancourt M, Rodríguez AB, Bevan A, Bezawada Y, Bezerra TJC, Bhardwaj A, Bhatnagar V,… See abstract for full author list ➔ Abud AA, et al. Eur Phys J C Part Fields. 2022;82(7):618. doi: 10.1140/epjc/s10052-022-10549-w. Epub 2022 Jul 16. Eur Phys J C Part Fields. 2022. PMID: 35859696 Free PMC article.
37 results