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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
1970 1
1971 1
1972 2
1973 1
1977 1
1978 5
1979 2
1980 1
1981 3
1982 4
1983 4
1984 5
1985 6
1986 3
1987 3
1988 6
1989 6
1990 5
1991 5
1992 5
1993 7
1994 5
1995 7
1996 10
1997 9
1998 8
1999 7
2000 13
2001 15
2002 13
2003 14
2004 18
2005 18
2006 19
2007 21
2008 30
2009 21
2010 13
2011 22
2012 27
2013 16
2014 41
2015 38
2016 41
2017 39
2018 44
2019 37
2020 62
2021 80
2022 80
2023 76
2024 31

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862 results

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Page 1
Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis.
Chalmers JD, Haworth CS, Metersky ML, Loebinger MR, Blasi F, Sibila O, O'Donnell AE, Sullivan EJ, Mange KC, Fernandez C, Zou J, Daley CL; WILLOW Investigators. Chalmers JD, et al. N Engl J Med. 2020 Nov 26;383(22):2127-2137. doi: 10.1056/NEJMoa2021713. Epub 2020 Sep 7. N Engl J Med. 2020. PMID: 32897034 Clinical Trial.
Sleep Patterns and the Risk of Acute Stroke: Results From the INTERSTROKE International Case-Control Study.
Mc Carthy CE, Yusuf S, Judge C, Alvarez-Iglesias A, Hankey GJ, Oveisgharan S, Damasceno A, Iversen HK, Rosengren A, Avezum A, Lopez-Jaramillo P, Xavier D, Wang X, Rangarajan S, O'Donnell M; for INTERSTROKE. Mc Carthy CE, et al. Neurology. 2023 May 23;100(21):e2191-e2203. doi: 10.1212/WNL.0000000000207249. Epub 2023 Apr 5. Neurology. 2023. PMID: 37019662 Free PMC article.
Selinexor: Targeting a novel pathway in multiple myeloma.
Mo CC, Yee AJ, Midha S, Hartley-Brown MA, Nadeem O, O'Donnell EK, Bianchi G, Sperling AS, Laubach JP, Richardson PG. Mo CC, et al. EJHaem. 2023 May 15;4(3):792-810. doi: 10.1002/jha2.709. eCollection 2023 Aug. EJHaem. 2023. PMID: 37601856 Free PMC article. Review.
New Perspectives on Antimicrobial Agents: Imipenem-Relebactam.
O'Donnell JN, Lodise TP. O'Donnell JN, et al. Antimicrob Agents Chemother. 2022 Jul 19;66(7):e0025622. doi: 10.1128/aac.00256-22. Epub 2022 Jun 21. Antimicrob Agents Chemother. 2022. PMID: 35727059 Free PMC article. Review.
Relebactam, a bicyclic diazabicyclooctane, has no direct antimicrobial activity but provides reliable inhibition of many Ambler class A and class C enzymes. It is currently approved for the treatment of adult patients with hospital-acquired bacterial pneumonia and ventilat …
Relebactam, a bicyclic diazabicyclooctane, has no direct antimicrobial activity but provides reliable inhibition of many Ambler class A and …
Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.
Rogers MA, Bartoli-Leonard F, Zheng KH, Small AM, Chen HY, Clift CL, Asano T, Kuraoka S, Blaser MC, Perez KA, Natarajan P, Yeang C, Stroes ESG, Tsimikas S, Engert JC, Thanassoulis G, O'Donnell CJ, Aikawa M, Singh SA, Aikawa E. Rogers MA, et al. Circulation. 2024 Jan 30;149(5):391-401. doi: 10.1161/CIRCULATIONAHA.123.066822. Epub 2023 Nov 8. Circulation. 2024. PMID: 37937463
Glycolytic reprogramming fuels myeloid cell-driven hypercoagulability.
Rehill AM, Leon G, McCluskey S, Schoen I, Hernandez-Santana Y, Annett S, Klavina P, Robson T, Curtis AM, Renné T, Hussey S, O'Donnell JS, Walsh PT, Preston RJS. Rehill AM, et al. J Thromb Haemost. 2024 Feb;22(2):394-409. doi: 10.1016/j.jtha.2023.10.006. Epub 2023 Oct 20. J Thromb Haemost. 2024. PMID: 37865288 Free article.
Macrophage polarization or activation markedly increased endothelial protein C receptor (EPCR) expression on monocytes and macrophages, leading to increased myeloid cell-dependent protein C activation. ...Adipose tissue macrophages from obese mice fed a high-fat die …
Macrophage polarization or activation markedly increased endothelial protein C receptor (EPCR) expression on monocytes and macrophage …
Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands.
Bagdanoff JT, Smith TM, Allan M, O'Donnell P, Nguyen Z, Moore EA, Baird J, Wang S, Subramanian V, Tigani B, Nettleton DO, Monovich LG, Lewis I, Flyer AN, Granda B, Blankenship JW, Barnes-Seeman D, Clairmont KB. Bagdanoff JT, et al. Cell Chem Biol. 2023 Jan 19;30(1):97-109.e9. doi: 10.1016/j.chembiol.2022.12.003. Epub 2023 Jan 9. Cell Chem Biol. 2023. PMID: 36626903 Free article.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting the degradation of hepatic LDL receptors (LDLRs). Current therapeutic approaches use antibodies that disrupt PCSK9 binding to LDLR to redu …
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promotin …
A Phase 2 randomised study to establish efficacy, safety and dosing of a novel oral cathepsin C inhibitor, BI 1291583, in adults with bronchiectasis: Airleaf.
Chalmers JD, Gupta A, Chotirmall SH, Armstrong A, Eickholz P, Hasegawa N, McShane PJ, O'Donnell AE, Shteinberg M, Watz H, Eleftheraki A, Diefenbach C, Sauter W. Chalmers JD, et al. ERJ Open Res. 2023 Jun 26;9(3):00633-2022. doi: 10.1183/23120541.00633-2022. eCollection 2023 May. ERJ Open Res. 2023. PMID: 37465817 Free PMC article.
New therapies are needed to prevent exacerbations, improve quality of life and slow disease progression in bronchiectasis. Inhibition of cathepsin C (CatC) activity has the potential to decrease activation of neutrophil-derived serine proteases in patients with bronchiecta …
New therapies are needed to prevent exacerbations, improve quality of life and slow disease progression in bronchiectasis. Inhibition of cat …
Plasma Protein Profile of Carotid Artery Atherosclerosis and Atherosclerotic Outcomes: Meta-Analyses and Mendelian Randomization Analyses.
Lind L, Gigante B, Borné Y, Feldreich T, Leppert J, Hedberg P, Östgren CJ, Nyström FH, Sundström J, Ärnlöv J, Baldassarre D, Tremoli E, Veglia F, Hamsten A, O'Donnell CJ, Franceschini N, Orho-Melander M, Nilsson J, Melander O, Engström G, Mälarstig A. Lind L, et al. Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1777-1788. doi: 10.1161/ATVBAHA.120.315597. Epub 2021 Mar 4. Arterioscler Thromb Vasc Biol. 2021. PMID: 33657885 Free PMC article.
Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study.
Murphy RP, Reddin C, Rosengren A, Judge C, Hankey GJ, Ferguson J, Alvarez-Iglesias A, Oveisgharan S, Wasay M, McDermott C, Iversen HK, Lanas F, Al-Hussain F, Czlonkowska A, Oguz A, Ogunniyi A, Damasceno A, Xavier D, Avezum A, Wang X, Langhorne P, Yusuf S, O'Donnell M; INTERSTROKE investigators. Murphy RP, et al. Neurology. 2023 Apr 25;100(17):e1787-e1798. doi: 10.1212/WNL.0000000000207093. Epub 2023 Mar 8. Neurology. 2023. PMID: 36889922 Free PMC article.
862 results