Isotope-labeled amyloid-β does not transmit to the brain in a prion-like manner after peripheral administration.
Brackhan M, Calza G, Lundgren K, Bascuñana P, Brüning T, Soliymani R, Kumar R, Abelein A, Baumann M, Lalowski M, Pahnke J.
Brackhan M, et al.
EMBO Rep. 2022 Jul 5;23(7):e54405. doi: 10.15252/embr.202154405. Epub 2022 May 27.
EMBO Rep. 2022.
PMID: 35620875
Free PMC article.
Here, we use a proteomic approach combining stable isotope labeling of mammals and targeted mass spectrometry. Specifically, we generate (13) C-isotope-labeled brain extracts from mice expressing human amyloid-beta and track (13) C-lysine-labeled amyloid-beta after …
Here, we use a proteomic approach combining stable isotope labeling of mammals and targeted mass spectrometry. Specifically, we generate (13 …