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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
1963 2
1964 6
1965 1
1967 1
1968 1
1970 1
1971 1
1975 2
1976 3
1978 1
1980 3
1981 8
1982 11
1983 15
1984 15
1985 11
1986 18
1987 21
1988 30
1989 30
1990 51
1991 101
1992 108
1993 144
1994 158
1995 172
1996 185
1997 210
1998 198
1999 215
2000 245
2001 217
2002 236
2003 267
2004 288
2005 320
2006 316
2007 346
2008 340
2009 355
2010 434
2011 464
2012 487
2013 571
2014 576
2015 582
2016 610
2017 692
2018 711
2019 724
2020 890
2021 914
2022 914
2023 790
2024 190

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12,851 results

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Page 1
Alternagin-C (ALT-C), a disintegrin-like protein, attenuates alpha2beta1 integrin and VEGF receptor 2 signaling resulting in angiogenesis inhibition.
Dos Santos PK, Altei WF, Danilucci TM, Lino RLB, Pachane BC, Nunes ACC, Selistre-de-Araujo HS. Dos Santos PK, et al. Biochimie. 2020 Jul;174:144-158. doi: 10.1016/j.biochi.2020.04.023. Epub 2020 Apr 30. Biochimie. 2020. PMID: 32360415 Free article.
Furthermore, ALT-C increased the content of the autophagic markers LC3B and Beclin-1 in the presence of VEGF, which is associated with decreased angiogenesis. In conclusion, we suggest that ALT-C, after binding to alpha(2)beta(1) integrin, inhibits VEG …
Furthermore, ALT-C increased the content of the autophagic markers LC3B and Beclin-1 in the presence of VEGF, which is associa …
Peginterferon alpha-2a (40KD) plus ribavirin: a review of its use in the management of patients with chronic hepatitis C and persistently 'normal' ALT levels.
Keating GM, Plosker GL. Keating GM, et al. Drugs. 2005;65(4):521-36. doi: 10.2165/00003495-200565040-00006. Drugs. 2005. PMID: 15733013 Review.
Combination therapy with subcutaneous peginterferon alpha-2a (40KD) [Pegasys] plus oral ribavirin (Copegus) has been evaluated previously in patients with chronic hepatitis C and elevated ALT levels. A recent randomised, nonblind, multicentre trial examined the effi …
Combination therapy with subcutaneous peginterferon alpha-2a (40KD) [Pegasys] plus oral ribavirin (Copegus) has been evaluated previously in …
Chronic Hepatitis C: Acute Exacerbation and Alanine Aminotransferase Flare.
Kanda T, Matsumoto N, Ishii T, Arima S, Shibuya S, Honda M, Sasaki-Tanaka R, Masuzaki R, Kanezawa S, Nishizawa T, Gon Y, Ogawa M, Kogure H. Kanda T, et al. Viruses. 2023 Jan 8;15(1):183. doi: 10.3390/v15010183. Viruses. 2023. PMID: 36680223 Free PMC article. Review.
HCV genotype 2 infection, the use of rituximab, and a higher dose of corticosteroid are factors associated with HCV acute exacerbation and ALT flare. Treatment regimens for cancer have been interrupted or changed due to ALT flare due to HCV infection in some patient …
HCV genotype 2 infection, the use of rituximab, and a higher dose of corticosteroid are factors associated with HCV acute exacerbation and …
Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cells.
Jones CY, Williams CL, Moreno SP, Morris DK, Mondello C, Karlseder J, Bertuch AA. Jones CY, et al. J Biol Chem. 2023 May;299(5):104665. doi: 10.1016/j.jbc.2023.104665. Epub 2023 Mar 30. J Biol Chem. 2023. PMID: 37003504 Free PMC article.
Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT). Currently, the primary ALT biomarker is the C-circle, a type of circular DNA with extrachromosomal telomere repeats (cECTRs …
Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT
Treatment of patients with chronic hepatitis C and normal ALT levels.
Tassopoulos NC. Tassopoulos NC. J Hepatol. 1999;31 Suppl 1:193-6. doi: 10.1016/s0168-8278(99)80400-0. J Hepatol. 1999. PMID: 10622586 Review.
A certain group of patients with chronic hepatitis C have normal serum alanine aminotransferase (ALT) levels, despite the replication of hepatitis C virus (HCV) in infected liver cells and detection of HCV RNA in serum. ...These response rates are similar to …
A certain group of patients with chronic hepatitis C have normal serum alanine aminotransferase (ALT) levels, despite the repl …
[Alanine aminotransferase (ALT)].
Sakagishi Y. Sakagishi Y. Nihon Rinsho. 1995 May;53(5):1146-50. Nihon Rinsho. 1995. PMID: 7602770 Review. Japanese.
Amino acid sequence of c-ALT from rat and human liver has been wholly determined by Ishiguro et al. It is suggested that c-ALT is associated to the utilization of pyruvate in glycolysis and m-ALT is involved in the conversion of alanine to pyruv …
Amino acid sequence of c-ALT from rat and human liver has been wholly determined by Ishiguro et al. It is suggested that c
Low CDK Activity and Enhanced Degradation by APC/C(CDH1) Abolishes CtIP Activity and Alt-EJ in Quiescent Cells.
Li F, Mladenov E, Sun Y, Soni A, Stuschke M, Timmermann B, Iliakis G. Li F, et al. Cells. 2023 Jun 1;12(11):1530. doi: 10.3390/cells12111530. Cells. 2023. PMID: 37296650 Free PMC article.
Alt-EJ is an error-prone DNA double-strand break (DSBs) repair pathway coming to the fore when first-line repair pathways, c-NHEJ and HR, are defective or fail. ...Low levels of CtIP in G(1)-phase cells allow modest resection and alt-EJ, as compared to G(2)-p
Alt-EJ is an error-prone DNA double-strand break (DSBs) repair pathway coming to the fore when first-line repair pathways, c-N
Chronic hepatitis C and normal ALT: considerations for treatment.
Bacon BR. Bacon BR. Am J Gastroenterol. 2004 Sep;99(9):1706-7. doi: 10.1111/j.1572-0241.2004.40627.x. Am J Gastroenterol. 2004. PMID: 15330906
Improvements in the treatment of patients with chronic hepatitis C have progressed over the past 14 yr. Initially, treatment of patients with persistently normal ALT levels was not considered necessary. ...ALT levels are a poor marker of disease severity and/ …
Improvements in the treatment of patients with chronic hepatitis C have progressed over the past 14 yr. Initially, treatment of patie …
The C-Circle Biomarker Is Secreted by Alternative-Lengthening-of-Telomeres Positive Cancer Cells inside Exosomes and Provides a Blood-Based Diagnostic for ALT Activity.
Chen YY, Dagg R, Zhang Y, Lee JHY, Lu R, Martin La Rotta N, Sampl S, Korkut-Demirbaş M, Holzmann K, Lau LMS, Reddel RR, Henson JD. Chen YY, et al. Cancers (Basel). 2021 Oct 26;13(21):5369. doi: 10.3390/cancers13215369. Cancers (Basel). 2021. PMID: 34771533 Free PMC article.
C-Circles, self-primed telomeric C-strand templates for rolling circle amplification, are the only known alternative-lengthening-of-telomeres (ALT)-specific molecule. However, little is known about the biology of C-Circles and if they may be clinically
C-Circles, self-primed telomeric C-strand templates for rolling circle amplification, are the only known alternative-lengtheni
Telomerase suppresses formation of ALT-associated single-stranded telomeric C-circles.
Plantinga MJ, Pascarelli KM, Merkel AS, Lazar AJ, von Mehren M, Lev D, Broccoli D. Plantinga MJ, et al. Mol Cancer Res. 2013 Jun;11(6):557-67. doi: 10.1158/1541-7786.MCR-13-0013. Epub 2013 Mar 15. Mol Cancer Res. 2013. PMID: 23505069
Consistent with other reports, we found that liposarcomas containing APBs, but lacking telomerase expression, always contained C-rich circles (C-circles), and these C-circles were never present in the absence of APBs, indicating a tight link between these fea …
Consistent with other reports, we found that liposarcomas containing APBs, but lacking telomerase expression, always contained C-rich …
12,851 results
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