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Page 1
Stability of nucleic acid bases in concentrated sulfuric acid: Implications for the habitability of Venus' clouds.
Seager S, Petkowski JJ, Seager MD, Grimes JH Jr, Zinsli Z, Vollmer-Snarr HR, Abd El-Rahman MK, Wishart DS, Lee BL, Gautam V, Herrington L, Bains W, Darrow C. Seager S, et al. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2220007120. doi: 10.1073/pnas.2220007120. Epub 2023 Jun 12. Proc Natl Acad Sci U S A. 2023. PMID: 37307485 Free PMC article.
Here, we show that nucleic acid bases adenine, cytosine, guanine, thymine, and uracil, as well as 2,6-diaminopurine and the "core" nucleic acid bases purine and pyrimidine, are stable in sulfuric acid in the Venus cloud temperature and sulfuric acid concentration range, using UV …
Here, we show that nucleic acid bases adenine, cytosine, guanine, thymine, and uracil, as well as 2,6-diaminopurine and the "core" nucleic a …
Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization.
Xue B, Leyrat C, Grimes JM, Robinson RC. Xue B, et al. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4596-605. doi: 10.1073/pnas.1412271111. Epub 2014 Oct 13. Proc Natl Acad Sci U S A. 2014. PMID: 25313062 Free PMC article.
The second structure displays a more open nucleotide binding cleft on G-actin, which is typical of profilin:actin structures, with a concomitant disruption of the Tbeta4 C-terminal helix interaction. These structures, combined with biochemical assays and molecular dynamics …
The second structure displays a more open nucleotide binding cleft on G-actin, which is typical of profilin:actin structures, with a concomi …
Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase.
Wall ME, Francis SH, Corbin JD, Grimes K, Richie-Jannetta R, Kotera J, Macdonald BA, Gibson RR, Trewhella J. Wall ME, et al. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2380-5. doi: 10.1073/pnas.0534892100. Epub 2003 Feb 18. Proc Natl Acad Sci U S A. 2003. PMID: 12591946 Free PMC article.
The elongation is due to a change in the interaction between structured regulatory (R) and catalytic (C) domains. A model of cGMP binding to Delta(1-52)PKG-I beta indicates that elongation of Delta(1-52)PKG-I beta requires binding of cGMP to the low-affinity binding site o …
The elongation is due to a change in the interaction between structured regulatory (R) and catalytic (C) domains. A model of cGMP bin …
Terrestrial cooling in Northern Europe during the eocene-oligocene transition.
Hren MT, Sheldon ND, Grimes ST, Collinson ME, Hooker JJ, Bugler M, Lohmann KC. Hren MT, et al. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7562-7. doi: 10.1073/pnas.1210930110. Epub 2013 Apr 22. Proc Natl Acad Sci U S A. 2013. PMID: 23610424 Free PMC article.
Our data show a decrease in growing-season surface water temperatures (~10 C) during the Eocene-Oligocene transition, corresponding to an average decrease in mean annual air temperature of ~4-6 C from the Late Eocene to Early Oligocene. ...
Our data show a decrease in growing-season surface water temperatures (~10 C) during the Eocene-Oligocene transition, corresponding t …
The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death.
Grimes HL, Gilks CB, Chan TO, Porter S, Tsichlis PN. Grimes HL, et al. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14569-73. doi: 10.1073/pnas.93.25.14569. Proc Natl Acad Sci U S A. 1996. PMID: 8962093 Free PMC article.
The Gfi-1 repressor allows interleukin 2 (IL-2)-dependent T cells to escape G1 arrest induced by IL-2 withdrawal in culture and collaborates with c-myc and pim-1 for the induction of retrovirus-induced lymphomas in animals. ...The antiapoptotic properties of Gfi-1 provide …
The Gfi-1 repressor allows interleukin 2 (IL-2)-dependent T cells to escape G1 arrest induced by IL-2 withdrawal in culture and collaborates …
Isolation and characterization of a tumor cell surface antigen from spontaneously transformed BALB/c mouse fibroblasts.
Kamm AR, Grimes WJ. Kamm AR, et al. Proc Natl Acad Sci U S A. 1978 Dec;75(12):5912-6. doi: 10.1073/pnas.75.12.5912. Proc Natl Acad Sci U S A. 1978. PMID: 282613 Free PMC article.
This work describes the detection, isolation, and partial characterization of a BALB/c mouse fibroblast cell surface antigen. This antigen migrates as a polypeptide of approximately 100,000 daltons in a discontinuous sodium dodecyl sulfate/polyacrylamide gel electrophoresi …
This work describes the detection, isolation, and partial characterization of a BALB/c mouse fibroblast cell surface antigen. This an …
Electron transfer reactions in biological systems: the reduction of ferricytochrome c by chromous ions.
Grimes CJ, Piszkiewicz D, Fleischer EB. Grimes CJ, et al. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1408-12. doi: 10.1073/pnas.71.4.1408. Proc Natl Acad Sci U S A. 1974. PMID: 4364536 Free PMC article.
Chromous ion reacts with ferricytochrome c to yield a one-to-one Cr(III)-ferrocytochrome c complex. This material, when hydrolyzed by trypsin and subjected to chromatographic procedures, yielded two fragments containing chromium. ...The position of the chromic ion i …
Chromous ion reacts with ferricytochrome c to yield a one-to-one Cr(III)-ferrocytochrome c complex. This material, when hydrol …
Absorption of Near UV Light by HNO3/NO3(-) on Sapphire Surfaces.
Sangwan M, Stockwell WR, Stewart D, Zhu L. Sangwan M, et al. J Phys Chem A. 2016 May 12;120(18):2877-84. doi: 10.1021/acs.jpca.6b01648. Epub 2016 May 2. J Phys Chem A. 2016. PMID: 27111736
We obtained nitrate surface absorption cross section data over 320-350 nm range. We also modeled photolysis rates of HNO3/NO3(-) on urban grimes. Atmospheric implications of the results are discussed....
We obtained nitrate surface absorption cross section data over 320-350 nm range. We also modeled photolysis rates of HNO3/NO3(-) on urban …
Modeling the velocity field of the electroosmotic flow in charged capillaries and in capillary columns packed with charged particles: interstitial and intraparticle velocities in capillary electrochromatography systems.
Liapis AI, Grimes BA. Liapis AI, et al. J Chromatogr A. 2000 Apr 28;877(1-2):181-215. doi: 10.1016/s0021-9673(00)00185-0. J Chromatogr A. 2000. PMID: 10845799
The intraparticle Peclet number, Pe(int rap), for lysozyme was found to be greater than unity and this intraparticle convective mass transfer mechanism could contribute significantly, if the appropriate chemistry is employed in the mobile liquid phase and in the charged porous pa …
The intraparticle Peclet number, Pe(int rap), for lysozyme was found to be greater than unity and this intraparticle convective mass transfe …
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase.
Ahmed NN, Grimes HL, Bellacosa A, Chan TO, Tsichlis PN. Ahmed NN, et al. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3627-32. doi: 10.1073/pnas.94.8.3627. Proc Natl Acad Sci U S A. 1997. PMID: 9108028 Free PMC article.
Of these, IL-2Ra is required for high-affinity IL-2 binding, while IL-2R beta and IL-2R gamma(c) are required for the transduction of IL-2-generated signals. Signals transduced via the S region of the IL-2R beta (amino acids 267-322) in BAF/3 cells activate the phosphatidy …
Of these, IL-2Ra is required for high-affinity IL-2 binding, while IL-2R beta and IL-2R gamma(c) are required for the transduction of …
13 results