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CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice.
Hammerschmidt P, Steculorum SM, Bandet CL, Del Río-Martín A, Steuernagel L, Kohlhaas V, Feldmann M, Varela L, Majcher A, Quatorze Correia M, Klar RFU, Bauder CA, Kaya E, Porniece M, Biglari N, Sieben A, Horvath TL, Hornemann T, Brodesser S, Brüning JC. Hammerschmidt P, et al. Among authors: bandet cl. Nat Commun. 2023 Nov 29;14(1):7824. doi: 10.1038/s41467-023-42595-7. Nat Commun. 2023. PMID: 38016943 Free PMC article.
Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions.
Bandet CL, Mahfouz R, Véret J, Sotiropoulos A, Poirier M, Giussani P, Campana M, Philippe E, Blachnio-Zabielska A, Ballaire R, Le Liepvre X, Bourron O, Berkeš D, Górski J, Ferré P, Le Stunff H, Foufelle F, Hajduch E. Bandet CL, et al. Diabetes. 2018 Jul;67(7):1258-1271. doi: 10.2337/db17-0901. Epub 2018 May 14. Diabetes. 2018. PMID: 29759974 Free article.
Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats.
Campana M, Bellini L, Rouch C, Rachdi L, Coant N, Butin N, Bandet CL, Philippe E, Meneyrol K, Kassis N, Dairou J, Hajduch E, Colsch B, Magnan C, Le Stunff H. Campana M, et al. Among authors: bandet cl. Mol Metab. 2018 Feb;8:23-36. doi: 10.1016/j.molmet.2017.10.013. Epub 2017 Nov 7. Mol Metab. 2018. PMID: 29233519 Free PMC article.