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1956 21
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1967 16
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The following term was not found in PubMed: Byungjin
Page 1
Did you mean yungjin ku (1 results)?
The pendulum of the Ku-Ku clock.
Shibata A, Jeggo P, Löbrich M. Shibata A, et al. DNA Repair (Amst). 2018 Nov;71:164-171. doi: 10.1016/j.dnarep.2018.08.020. Epub 2018 Aug 23. DNA Repair (Amst). 2018. PMID: 30177438 Free article. Review.
Emerging evidence has suggested that Ku is the first protein binding most, if not all, DSBs, and creates a block to resection. ...Our review reveals that Ku plays an active role in determining pathway choice and exposes similarities yet distinctions in the progressi …
Emerging evidence has suggested that Ku is the first protein binding most, if not all, DSBs, and creates a block to resection. ...Our …
Anti-Ku-positive juvenile dermatomyositis.
Cotter C, Rudd E, Williamson E, Philippidou M, Tewari A. Cotter C, et al. Clin Exp Dermatol. 2022 Feb;47(2):425-427. doi: 10.1111/ced.14937. Epub 2021 Oct 8. Clin Exp Dermatol. 2022. PMID: 34528293 No abstract available.
Plugged into the Ku-DNA hub: The NHEJ network.
Frit P, Ropars V, Modesti M, Charbonnier JB, Calsou P. Frit P, et al. Prog Biophys Mol Biol. 2019 Oct;147:62-76. doi: 10.1016/j.pbiomolbio.2019.03.001. Epub 2019 Mar 6. Prog Biophys Mol Biol. 2019. PMID: 30851288 Review.
Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized proteins with scaffolding and/or enzymatic properties. To shed light on these dynamic interplays, we review here current knowledge on protein …
Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized p …
The Ku complex: recent advances and emerging roles outside of non-homologous end-joining.
Abbasi S, Parmar G, Kelly RD, Balasuriya N, Schild-Poulter C. Abbasi S, et al. Cell Mol Life Sci. 2021 May;78(10):4589-4613. doi: 10.1007/s00018-021-03801-1. Epub 2021 Apr 15. Cell Mol Life Sci. 2021. PMID: 33855626 Free PMC article. Review.
Some advances have been driven by clarification of Ku's structure, including the original Ku crystal structure and the more recent Ku-DNA-PK(cs) crystallography, cryogenic electron microscopy (cryoEM) studies, and the identification of various post-translatio …
Some advances have been driven by clarification of Ku's structure, including the original Ku crystal structure and the more re …
Noncanonical functions of Ku may underlie essentiality in human cells.
Kelly RD, Parmar G, Bayat L, Maitland MER, Lajoie GA, Edgell DR, Schild-Poulter C. Kelly RD, et al. Sci Rep. 2023 Jul 27;13(1):12162. doi: 10.1038/s41598-023-39166-7. Sci Rep. 2023. PMID: 37500706 Free PMC article.
Here, we established conditional Ku70 knockout cells using CRISPR/Cas9 editing to study the essentiality of Ku70 function. While we observed loss of cell viability upon Ku depletion, we did not detect significant changes in telomere length, nor did we record lethal levels …
Here, we established conditional Ku70 knockout cells using CRISPR/Cas9 editing to study the essentiality of Ku70 function. While we observed …
The Ku heterodimer: function in DNA repair and beyond.
Fell VL, Schild-Poulter C. Fell VL, et al. Mutat Res Rev Mutat Res. 2015 Jan-Mar;763:15-29. doi: 10.1016/j.mrrev.2014.06.002. Epub 2014 Jul 4. Mutat Res Rev Mutat Res. 2015. PMID: 25795113 Review.
Ku also functions to prevent tumorigenesis and senescence since Ku-deficient mice show increased cancer incidence and early onset of aging. Overall, Ku function is critical to the maintenance of genomic integrity and to proper cellular and organismal developm …
Ku also functions to prevent tumorigenesis and senescence since Ku-deficient mice show increased cancer incidence and early on …
PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair.
Pan Q, Luo P, Shi C. Pan Q, et al. J Biol Chem. 2023 Aug;299(8):105032. doi: 10.1016/j.jbc.2023.105032. Epub 2023 Jul 10. J Biol Chem. 2023. PMID: 37437887 Free PMC article.
Mechanistically, PC4 interacts with poly (ADP-ribose) polymerase 1 and directs Ku complex PARylation, resulting in the successful recruitment of the Ku complex to damaged chromatin and increasing the efficiency of nonhomologous end joining repair. ...
Mechanistically, PC4 interacts with poly (ADP-ribose) polymerase 1 and directs Ku complex PARylation, resulting in the successful rec …
The Ku complex promotes DNA end-bridging and this function is antagonized by Tel1/ATM kinase.
Rinaldi C, Pizzul P, Casari E, Mangiagalli M, Tisi R, Longhese MP. Rinaldi C, et al. Nucleic Acids Res. 2023 Feb 28;51(4):1783-1802. doi: 10.1093/nar/gkad062. Nucleic Acids Res. 2023. PMID: 36762474 Free PMC article.
Impairing histone removal around DSBs either by eliminating Tel1 kinase activity or nucleosome remodelers enhances Ku persistence at DSBs and DSB bridging, suggesting that Tel1 antagonizes the Ku function in supporting end-tethering by promoting nucleosome removal a …
Impairing histone removal around DSBs either by eliminating Tel1 kinase activity or nucleosome remodelers enhances Ku persistence at …
Ku circles the telomere?
Sell C. Sell C. Aging (Albany NY). 2011 Apr;3(4):344-5. doi: 10.18632/aging.100321. Aging (Albany NY). 2011. PMID: 21732567 Free PMC article. No abstract available.
The phenotype of myositis patients with anti-Ku autoantibodies.
Casal-Dominguez M, Pinal-Fernandez I, Derfoul A, Graf R, Michelle H, Albayda J, Tiniakou E, Adler B, Danoff SK, Lloyd TE, Christoper-Stine L, Paik JJ, Mammen AL. Casal-Dominguez M, et al. Semin Arthritis Rheum. 2021 Aug;51(4):728-734. doi: 10.1016/j.semarthrit.2021.04.012. Epub 2021 Apr 28. Semin Arthritis Rheum. 2021. PMID: 34144382 Free PMC article.
OBJECTIVES: To define the clinical features of anti-Ku-positive myositis patients and to determine the reliability of the Euroline assay to detect anti-Ku autoantibodies. ...Anti-Ku-positive patients never developed calcinosis. CONCLUSIONS: The phenotype of a …
OBJECTIVES: To define the clinical features of anti-Ku-positive myositis patients and to determine the reliability of the Euroline as …
326,258 results
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