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Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis.
Isik B, Thaler R, Goksu BB, Conley SM, Al-Khafaji H, Mohan A, Afarideh M, Abumoawad AM, Zhu XY, Krier JD, Saadiq IM, Tang H, Eirin A, Hickson LJ, van Wijnen AJ, Textor SC, Lerman LO, Herrmann SM. Isik B, et al. Among authors: goksu bb. Stem Cell Res Ther. 2021 Apr 14;12(1):240. doi: 10.1186/s13287-021-02310-z. Stem Cell Res Ther. 2021. PMID: 33853680 Free PMC article.
Effect of Hypoxia Preconditioning on the Regenerative Capacity of Adipose Tissue Derived Mesenchymal Stem Cells in a Model of Renal Artery Stenosis.
Farooqui N, Mohan A, Isik B, Goksu BB, Thaler R, Zhu XY, Krier JD, Saadiq IM, Ferguson CM, Jordan KL, Tang H, Textor SC, Hickson TJ, van Wijnen AJ, Eirin A, Lerman LO, Herrmann SM. Farooqui N, et al. Among authors: goksu bb. Stem Cells. 2023 Jan 30;41(1):50-63. doi: 10.1093/stmcls/sxac073. Stem Cells. 2023. PMID: 36250949 Free PMC article.
In a Phase 1a escalating clinical trial, autologous mesenchymal stem cell infusion for renovascular disease increases blood flow and the glomerular filtration rate while reducing inflammatory biomarkers and blood pressure.
Abumoawad A, Saad A, Ferguson CM, Eirin A, Herrmann SM, Hickson LJ, Goksu BB, Bendel E, Misra S, Glockner J, Dietz AB, Lerman LO, Textor SC. Abumoawad A, et al. Among authors: goksu bb. Kidney Int. 2020 Apr;97(4):793-804. doi: 10.1016/j.kint.2019.11.022. Epub 2019 Dec 13. Kidney Int. 2020. PMID: 32093917 Free PMC article. Clinical Trial.