Hepatocyte Adenosine Kinase Promotes Excessive Fat Deposition and Liver Inflammation.
Li H, Zheng J, Xu Q, Yang Y, Zhou J, Guo X, Cai Y, Cai JJ, Xie L, Awika J, Han X, Li Q, Kennedy L, Francis H, Glaser S, Huo Y, Alpini G, Wu C.
Li H, et al.
Gastroenterology. 2023 Jan;164(1):134-146. doi: 10.1053/j.gastro.2022.09.027. Epub 2022 Sep 28.
Gastroenterology. 2023.
PMID: 36181835
Free PMC article.
RESULTS: Whereas patients with nonalcoholic fatty liver disease had increased hepatic ADK levels, mice with hepatocyte-specific ADK disruption displayed decreased hepatic fat deposition on a chow diet and were protected from diet-induced excessive hepatic fat deposition an …
RESULTS: Whereas patients with nonalcoholic fatty liver disease had increased hepatic ADK levels, mice with hepatocyte-specific ADK disrupti …