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Page 1
Retinal remodeling in human retinitis pigmentosa.
Jones BW, Pfeiffer RL, Ferrell WD, Watt CB, Marmor M, Marc RE. Jones BW, et al. Exp Eye Res. 2016 Sep;150:149-65. doi: 10.1016/j.exer.2016.03.018. Epub 2016 Mar 26. Exp Eye Res. 2016. PMID: 27020758 Free PMC article. Review.
This study, using computational molecular phenotyping (CMP) seeks to advance our understanding of the retinal remodeling process in humans. We describe cone mediated preservation of overall topology, retinal reprogramming in the earliest stages of the disease …
This study, using computational molecular phenotyping (CMP) seeks to advance our understanding of the retinal remodeling process in h …
Seasonal and post-trauma remodeling in cone-dominant ground squirrel retina.
Merriman DK, Sajdak BS, Li W, Jones BW. Merriman DK, et al. Exp Eye Res. 2016 Sep;150:90-105. doi: 10.1016/j.exer.2016.01.011. Epub 2016 Jan 22. Exp Eye Res. 2016. PMID: 26808487 Free PMC article. Review.
With a photoreceptor mosaic containing 85% cones, the ground squirrel is one of the richest known mammalian sources of these important retinal cells. ...It is not yet clear if retinal cell types other than cones engage in torpor-associate …
With a photoreceptor mosaic containing 85% cones, the ground squirrel is one of the richest known mammalian sources of these i …
Fascins, a family of actin bundling proteins.
Edwards RA, Bryan J. Edwards RA, et al. Cell Motil Cytoskeleton. 1995;32(1):1-9. doi: 10.1002/cm.970320102. Cell Motil Cytoskeleton. 1995. PMID: 8674129 Review.
Subsequent work has shown that fascin bundles actin filaments in fertilized egg microvilli and filopodia of phagocytic coelomocytes [Otto et al., 1980: Cell Motil. 1:31-40; Otto and Bryan, 1981: Cell Motil. 1:179-192]. Fifteen years later, the molecular cloning of sea urch …
Subsequent work has shown that fascin bundles actin filaments in fertilized egg microvilli and filopodia of phagocytic coelomocytes [Otto et …
Metabolic changes and retinal remodeling in Heterozygous CRX mutant cats (CRX(RDY/+)).
Occelli LM, Jones BW, Cervantes TJ, Petersen-Jones SM. Occelli LM, et al. Exp Eye Res. 2023 Oct;235:109630. doi: 10.1016/j.exer.2023.109630. Epub 2023 Aug 23. Exp Eye Res. 2023. PMID: 37625575
Initially there was preservation of inner retinal cells such as bipolar, amacrine and horizontal cells but with time migration of the deafferented neurons occurred. ...These findings suggest that therapy dependent on targeting inner retinal cells …
Initially there was preservation of inner retinal cells such as bipolar, amacrine and horizontal cells but with time mi …
PTEN Regulates Dendritic Arborization by Decreasing Microtubule Polymerization Rate.
Getz SA, Tariq K, Marchand DH, Dickson CR, Howe Vi JR, Skelton PD, Wang W, Li M, Barry JM, Hong J, Luikart BW. Getz SA, et al. J Neurosci. 2022 Mar 9;42(10):1945-1957. doi: 10.1523/JNEUROSCI.1835-21.2022. Epub 2022 Jan 31. J Neurosci. 2022. PMID: 35101965 Free PMC article.
We also found an increase in MT polymerization rate in Pten KO dendritic growth cones. Reducing MT polymerization rate to the WT level was sufficient to reduce dendritic overgrowth in Pten KO neurons in vitro and in vivo Finally, we found that rescue of dendritic overgrowt …
We also found an increase in MT polymerization rate in Pten KO dendritic growth cones. Reducing MT polymerization rate to the WT leve …
Retinal remodeling triggered by photoreceptor degenerations.
Jones BW, Watt CB, Frederick JM, Baehr W, Chen CK, Levine EM, Milam AH, Lavail MM, Marc RE. Jones BW, et al. J Comp Neurol. 2003 Sep 8;464(1):1-16. doi: 10.1002/cne.10703. J Comp Neurol. 2003. PMID: 12866125
Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. ...Although some neurons die, survivors express molecular signatures characteristic of normal bipolar, amacrine, and ganglion cells. Remodeling in human and rodent reti …
Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. ...Although some neurons die, survi …
Prolonged depolarization in turtle cones evoked by current injection and stimulation of the receptive field surround.
Burkhardt DA, Gottesman J, Thoreson WB. Burkhardt DA, et al. J Physiol. 1988 Dec;407:329-48. doi: 10.1113/jphysiol.1988.sp017418. J Physiol. 1988. PMID: 3256619 Free PMC article.
The prolonged depolarization is thus apparently generated by a voltage-sensitive mechanism intrinsic to the cone. 5. Brief depolarizing spikes were recorded in a small fraction of cones. ...The graded depolarization is probably a manifestation of the depolarizing in …
The prolonged depolarization is thus apparently generated by a voltage-sensitive mechanism intrinsic to the cone. 5. Brief depolarizi …
The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth.
Bryan BA, Cai Y, Liu M. Bryan BA, et al. J Neurosci Res. 2006 May 15;83(7):1151-9. doi: 10.1002/jnr.20814. J Neurosci Res. 2006. PMID: 16496360
We have recently reported that a Rho-family guanine nucleotide exchange factor, GEFT, modulates dendrite spine morphology and basal neurite outgrowth in primary hippocampal neurons and Neuro2A cells, respectively. Here we demonstrate that GEFT protein is highly expressed i …
We have recently reported that a Rho-family guanine nucleotide exchange factor, GEFT, modulates dendrite spine morphology and basal neurite …
Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology.
Huang DY, Weisgraber KH, Strittmatter WJ, Matthew WD. Huang DY, et al. Exp Neurol. 1995 Dec;136(2):251-7. doi: 10.1006/exnr.1995.1101. Exp Neurol. 1995. PMID: 7498414
In addition, neurons grown on laminin-apoE substrates have larger growth cones, increased neuritic branching, and flattened cell bodies compared to neurons grown on laminin alone. ...
In addition, neurons grown on laminin-apoE substrates have larger growth cones, increased neuritic branching, and flattened cell bodi …