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Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria.
Annunziato G, Spadini C, Marchetti M, Franko N, Pavone M, Iannarelli M, Bruno A, Pieroni M, Bettati S, Cabassi CS, Campanini B, Costantino G. Annunziato G, et al. Among authors: bruno a. Pharmaceuticals (Basel). 2022 Jun 20;15(6):766. doi: 10.3390/ph15060766. Pharmaceuticals (Basel). 2022. PMID: 35745685 Free PMC article.
Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants.
Magalhães J, Franko N, Raboni S, Annunziato G, Tammela P, Bruno A, Bettati S, Armao S, Spadini C, Cabassi CS, Mozzarelli A, Pieroni M, Campanini B, Costantino G. Magalhães J, et al. Among authors: bruno a. Pharmaceuticals (Basel). 2021 Feb 23;14(2):174. doi: 10.3390/ph14020174. Pharmaceuticals (Basel). 2021. PMID: 33672408 Free PMC article.
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design.
Magalhães J, Franko N, Annunziato G, Welch M, Dolan SK, Bruno A, Mozzarelli A, Armao S, Jirgensons A, Pieroni M, Costantino G, Campanini B. Magalhães J, et al. Among authors: bruno a. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1444-1452. doi: 10.1080/14756366.2018.1512596. J Enzyme Inhib Med Chem. 2018. PMID: 30221554 Free PMC article.
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR.
Annunziato G, Pieroni M, Benoni R, Campanini B, Pertinhez TA, Pecchini C, Bruno A, Magalhães J, Bettati S, Franko N, Mozzarelli A, Costantino G. Annunziato G, et al. Among authors: bruno a. J Enzyme Inhib Med Chem. 2016;31(sup4):78-87. doi: 10.1080/14756366.2016.1218486. Epub 2016 Aug 31. J Enzyme Inhib Med Chem. 2016. PMID: 27578398