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Showing results for brain obermeyer
Search for Brian Obermeyer instead (1 results)
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, Kim AS, Lindblad AS, Palesch YY; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. Johnston SC, et al. N Engl J Med. 2018 Jul 19;379(3):215-225. doi: 10.1056/NEJMoa1800410. Epub 2018 May 16. N Engl J Med. 2018. PMID: 29766750 Free PMC article. Clinical Trial.
Influencing neuroplasticity in stroke treatment with advanced biomaterials-based approaches.
Obermeyer JM, Ho E, Gracias A, Shoichet MS. Obermeyer JM, et al. Adv Drug Deliv Rev. 2019 Aug;148:204-218. doi: 10.1016/j.addr.2018.12.012. Epub 2018 Dec 21. Adv Drug Deliv Rev. 2019. PMID: 30579882 Review.
Since the early 1990s, we have known that the adult brain is not static and has the capacity to repair itself. The delivery of various therapeutic factors and cells have resulted in some exciting pre-clinical and clinical outcomes in stroke models by targeting post-injury …
Since the early 1990s, we have known that the adult brain is not static and has the capacity to repair itself. The delivery of variou …
Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioral Recovery and Tissue Repair in Stroke-Injured Rats.
Obermeyer JM, Tuladhar A, Payne SL, Ho E, Morshead CM, Shoichet MS. Obermeyer JM, et al. Tissue Eng Part A. 2019 Aug;25(15-16):1175-1187. doi: 10.1089/ten.TEA.2018.0215. Epub 2019 Feb 27. Tissue Eng Part A. 2019. PMID: 30612516
We developed a biocomposite that can be mixed with brain-derived neurotrophic factor (BDNF) and dispensed onto the surface of the brain to provide sustained, local release of the protein using a procedure that avoids additional damage to neural tissue. ...We demonst …
We developed a biocomposite that can be mixed with brain-derived neurotrophic factor (BDNF) and dispensed onto the surface of the …
Injectable hydrogel enables local and sustained co-delivery to the brain: Two clinically approved biomolecules, cyclosporine and erythropoietin, accelerate functional recovery in rat model of stroke.
Tuladhar A, Obermeyer JM, Payne SL, Siu RCW, Zand S, Morshead CM, Shoichet MS. Tuladhar A, et al. Biomaterials. 2020 Mar;235:119794. doi: 10.1016/j.biomaterials.2020.119794. Epub 2020 Jan 16. Biomaterials. 2020. PMID: 31981761
Therapeutic delivery to the brain is limited by the blood-brain barrier and is exacerbated by off-target effects associated with systemic delivery, thereby precluding many potential therapies from even being tested. ...Using a rodent model of stroke, we employed an …
Therapeutic delivery to the brain is limited by the blood-brain barrier and is exacerbated by off-target effects associated wi …
Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease.
Boeynaems S, Ma XR, Yeong V, Ginell GM, Chen JH, Blum JA, Nakayama L, Sanyal A, Briner A, Haver DV, Pauwels J, Ekman A, Schmidt HB, Sundararajan K, Porta L, Lasker K, Larabell C, Hayashi MAF, Kundaje A, Impens F, Obermeyer A, Holehouse AS, Gitler AD. Boeynaems S, et al. bioRxiv [Preprint]. 2023 Mar 9:2023.03.09.531820. doi: 10.1101/2023.03.09.531820. bioRxiv. 2023. PMID: 36945394 Free PMC article. Preprint.
Expression of cholinergic markers in the pons of Flinders rats.
Greco MA, Magner M, Overstreet D, Shiromani PJ. Greco MA, et al. Brain Res Mol Brain Res. 1998 Apr;55(2):232-6. doi: 10.1016/s0169-328x(98)00002-3. Brain Res Mol Brain Res. 1998. PMID: 9582425
Overstreet, M.A. Gilliland, D. Russell, B.M. Bergmann, W.H. Obermeyer, Increased basal REM sleep but no difference in dark induction or light suppression of REM sleep in Flinders rats with cholinergic supersensitivity, Neuropsychopharmacology 15 (1996) 45-51; P.J. ...
Overstreet, M.A. Gilliland, D. Russell, B.M. Bergmann, W.H. Obermeyer, Increased basal REM sleep but no difference in dark induction …
Initial cell maturity changes following transplantation in a hyaluronan-based hydrogel and impacts therapeutic success in the stroke-injured rodent brain.
Payne SL, Tuladhar A, Obermeyer JM, Varga BV, Teal CJ, Morshead CM, Nagy A, Shoichet MS. Payne SL, et al. Biomaterials. 2019 Feb;192:309-322. doi: 10.1016/j.biomaterials.2018.11.020. Epub 2018 Nov 15. Biomaterials. 2019. PMID: 30468998
While preclinical studies have demonstrated that functional recovery can be obtained by transplanting an exogenous source of neural progenitors into the brain, it remains unknown at which stage of neuronal maturity cells will provide the most benefit. ...
While preclinical studies have demonstrated that functional recovery can be obtained by transplanting an exogenous source of neural progenit …
Sleep deprivation in the rat: II. Methodology.
Bergmann BM, Kushida CA, Everson CA, Gilliland MA, Obermeyer W, Rechtschaffen A. Bergmann BM, et al. Sleep. 1989 Feb;12(1):5-12. doi: 10.1093/sleep/12.1.5. Sleep. 1989. PMID: 2928625
23 results