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Showing results for brain dutta
Search for Brian Zutta instead (3 results)
Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.
Bolte AC, Dutta AB, Hurt ME, Smirnov I, Kovacs MA, McKee CA, Ennerfelt HE, Shapiro D, Nguyen BH, Frost EL, Lammert CR, Kipnis J, Lukens JR. Bolte AC, et al. Nat Commun. 2020 Sep 10;11(1):4524. doi: 10.1038/s41467-020-18113-4. Nat Commun. 2020. PMID: 32913280 Free PMC article.
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause severe deficits in meningeal lymphatic drainage that begin within hours and last out to at …
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of …
The meningeal transcriptional response to traumatic brain injury and aging.
Bolte AC, Shapiro DA, Dutta AB, Ma WF, Bruch KR, Kovacs MA, Royo Marco A, Ennerfelt HE, Lukens JR. Bolte AC, et al. Elife. 2023 Jan 3;12:e81154. doi: 10.7554/eLife.81154. Elife. 2023. PMID: 36594818 Free PMC article.
Here, we utilized high-throughput RNA sequencing (RNA-seq) techniques to investigate the transcriptional response of the meninges to traumatic brain injury (TBI) and aging in the sub-acute and chronic time frames. ...To better understand the differential outcomes between t …
Here, we utilized high-throughput RNA sequencing (RNA-seq) techniques to investigate the transcriptional response of the meninges to traumat …
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings.
Steinmetz NA, Aydin C, Lebedeva A, Okun M, Pachitariu M, Bauza M, Beau M, Bhagat J, Böhm C, Broux M, Chen S, Colonell J, Gardner RJ, Karsh B, Kloosterman F, Kostadinov D, Mora-Lopez C, O'Callaghan J, Park J, Putzeys J, Sauerbrei B, van Daal RJJ, Vollan AZ, Wang S, Welkenhuysen M, Ye Z, Dudman JT, Dutta B, Hantman AW, Harris KD, Lee AK, Moser EI, O'Keefe J, Renart A, Svoboda K, Häusser M, Haesler S, Carandini M, Harris TD. Steinmetz NA, et al. Science. 2021 Apr 16;372(6539):eabf4588. doi: 10.1126/science.abf4588. Science. 2021. PMID: 33859006 Free PMC article.
Improved site density and arrangement combined with newly created data processing methods enable automatic post hoc correction for brain movements, allowing recording from the same neurons for more than 2 months. ...
Improved site density and arrangement combined with newly created data processing methods enable automatic post hoc correction for brain …
Bassoon contributes to tau-seed propagation and neurotoxicity.
Martinez P, Patel H, You Y, Jury N, Perkins A, Lee-Gosselin A, Taylor X, You Y, Viana Di Prisco G, Huang X, Dutta S, Wijeratne AB, Redding-Ochoa J, Shahid SS, Codocedo JF, Min S, Landreth GE, Mosley AL, Wu YC, McKinzie DL, Rochet JC, Zhang J, Atwood BK, Troncoso J, Lasagna-Reeves CA. Martinez P, et al. Nat Neurosci. 2022 Dec;25(12):1597-1607. doi: 10.1038/s41593-022-01191-6. Epub 2022 Nov 7. Nat Neurosci. 2022. PMID: 36344699 Free PMC article.
We show that BSN exacerbates tau seeding and toxicity in both mouse and Drosophila models for tauopathy, and that BSN downregulation decreases tau spreading and overall disease pathology, rescuing synaptic and behavioral impairments and reducing brain atrophy. Our findings …
We show that BSN exacerbates tau seeding and toxicity in both mouse and Drosophila models for tauopathy, and that BSN downregulation decreas …
Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes.
Dutta S, Shah RB, Singhal S, Dutta SB, Bansal S, Sinha S, Haque M. Dutta S, et al. Drug Des Devel Ther. 2023 Jun 26;17:1907-1932. doi: 10.2147/DDDT.S409373. eCollection 2023. Drug Des Devel Ther. 2023. PMID: 37397787 Free PMC article. Review.
Its anticancer, antiproliferative and apoptosis-inducing effects on malignant cells might prove instrumental in the malignancy of organs like the breast, kidney, brain, ovary, lung, and endometrium. Preclinical studies have also shown some evidence of metformin's neuroprot …
Its anticancer, antiproliferative and apoptosis-inducing effects on malignant cells might prove instrumental in the malignancy of organs lik …
Preservation of cognitive function after brain irradiation.
Surendran HP, Narmadha MP, Kalavagunta S, Sasidharan A, Dutta D. Surendran HP, et al. J Oncol Pharm Pract. 2022 Jul;28(5):1182-1188. doi: 10.1177/10781552221077037. Epub 2022 Feb 3. J Oncol Pharm Pract. 2022. PMID: 35112915 Review.
OBJECTIVE: Approximately 50-90% of brain metastatic patients who receive radiation therapy (RT) exhibit cognitive decline which may affects the quality of life of cancer survivors. Hence preservation of cognitive functions in brain metastatic patients becomes import …
OBJECTIVE: Approximately 50-90% of brain metastatic patients who receive radiation therapy (RT) exhibit cognitive decline which may a …
Interrogating Metabolism in Brain Cancer.
Salzillo TC, Hu J, Nguyen L, Whiting N, Lee J, Weygand J, Dutta P, Pudakalakatti S, Millward NZ, Gammon ST, Lang FF, Heimberger AB, Bhattacharya PK. Salzillo TC, et al. Magn Reson Imaging Clin N Am. 2016 Nov;24(4):687-703. doi: 10.1016/j.mric.2016.07.003. Magn Reson Imaging Clin N Am. 2016. PMID: 27742110 Free PMC article. Review.
This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging technique …
This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnet …
Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier protection following ischemic stroke.
Luo S, Chen Y, Zhao R, Ma D, Zhao Y, Zhang Y, Jiang J, Yu W. Luo S, et al. J Ethnopharmacol. 2023 Oct 5;314:116640. doi: 10.1016/j.jep.2023.116640. Epub 2023 May 16. J Ethnopharmacol. 2023. PMID: 37196812 Free article.
Through metabolomics, 16S rRNA gene sequencing, and molecular biology techniques, research on the changes in the gut microbiota and blood-brain barrier (BBB) will highlight greater strategies for the treatment of stroke. ...CONCLUSION: SHT regulates the gut microbiota, inh …
Through metabolomics, 16S rRNA gene sequencing, and molecular biology techniques, research on the changes in the gut microbiota and blood- …
Bruchpiloting synaptic connections: Egfr in autophagy-mediated neuronal circuit development.
Chohan Y, Eitzman EA, Hawkins WD, Klionsky DJ. Chohan Y, et al. Autophagy. 2023 Jul;19(7):1899-1900. doi: 10.1080/15548627.2023.2217015. Epub 2023 May 27. Autophagy. 2023. PMID: 37243688
Dutta and colleagues found that increased autophagy due to Egfr inactivation results in decreased brp levels and, therefore, reduced neuronal connectivity. Through live cell imaging, it was determined that only the synaptic branches that accumulate both Egfr and brp are st …
Dutta and colleagues found that increased autophagy due to Egfr inactivation results in decreased brp levels and, therefore, reduced …
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.
Dutta S, Hornung S, Kruayatidee A, Maina KN, Del Rosario I, Paul KC, Wong DY, Duarte Folle A, Markovic D, Palma JA, Serrano GE, Adler CH, Perlman SL, Poon WW, Kang UJ, Alcalay RN, Sklerov M, Gylys KH, Kaufmann H, Fogel BL, Bronstein JM, Ritz B, Bitan G. Dutta S, et al. Acta Neuropathol. 2021 Sep;142(3):495-511. doi: 10.1007/s00401-021-02324-0. Epub 2021 May 15. Acta Neuropathol. 2021. PMID: 33991233 Free PMC article.
Exosomes isolated from blood by immunoprecipitation using CNS markers provide a window into the brain's biochemistry and may assist in distinguishing between PD and MSA. ...
Exosomes isolated from blood by immunoprecipitation using CNS markers provide a window into the brain's biochemistry and may a …
775 results