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Showing results for brain jefferies
Search for Brian Jefferies instead (3 results)
The default mode network in cognition: a topographical perspective.
Smallwood J, Bernhardt BC, Leech R, Bzdok D, Jefferies E, Margulies DS. Smallwood J, et al. Nat Rev Neurosci. 2021 Aug;22(8):503-513. doi: 10.1038/s41583-021-00474-4. Epub 2021 Jul 5. Nat Rev Neurosci. 2021. PMID: 34226715 Review.
The default mode network (DMN) is a set of widely distributed brain regions in the parietal, temporal and frontal cortex. These regions often show reductions in activity during attention-demanding tasks but increase their activity across multiple forms of complex cognition …
The default mode network (DMN) is a set of widely distributed brain regions in the parietal, temporal and frontal cortex. These regio …
Imaging the term neonatal brain.
Sorokan ST, Jefferies AL, Miller SP. Sorokan ST, et al. Paediatr Child Health. 2018 Aug;23(5):322-328. doi: 10.1093/pch/pxx161. Epub 2018 Jul 18. Paediatr Child Health. 2018. PMID: 30657135 Free PMC article. Review.
Brain imaging is important for the diagnosis and management of sick term neonates. Although ultrasound and computed tomography may provide some information, magnetic resonance imaging is now the brain imaging modality of choice because it is the most sensitive techn …
Brain imaging is important for the diagnosis and management of sick term neonates. Although ultrasound and computed tomography may pr …
Treatment options for progression or recurrence of glioblastoma: a network meta-analysis.
McBain C, Lawrie TA, Rogozińska E, Kernohan A, Robinson T, Jefferies S. McBain C, et al. Cochrane Database Syst Rev. 2021 May 4;5(1):CD013579. doi: 10.1002/14651858.CD013579.pub2. Cochrane Database Syst Rev. 2021. PMID: 34559423 Free PMC article. Review.
BACKGROUND: Glioblastoma (GBM) is a highly malignant brain tumour that almost inevitably progresses or recurs after first line standard of care. ...
BACKGROUND: Glioblastoma (GBM) is a highly malignant brain tumour that almost inevitably progresses or recurs after first line standa …
Uncommon low-grade brain tumors.
Ajithkumar T, Imbulgoda N, Rees E, Harris F, Horan G, Burke A, Jefferies S, Price S, Cross J, Allinson K. Ajithkumar T, et al. Neuro Oncol. 2019 Feb 14;21(2):151-166. doi: 10.1093/neuonc/noy151. Neuro Oncol. 2019. PMID: 30239861 Free PMC article. Review.
The 2016 World Health Organization (WHO) classification of primary central nervous system (CNS) tumors includes numerous uncommon (representing 1% of tumors) low-grade (grades I-II) brain neoplasms with varying clinical behaviors and outcomes. Generally, gross tumor or max …
The 2016 World Health Organization (WHO) classification of primary central nervous system (CNS) tumors includes numerous uncommon (represent …
C9orf72 in myeloid cells suppresses STING-induced inflammation.
McCauley ME, O'Rourke JG, Yáñez A, Markman JL, Ho R, Wang X, Chen S, Lall D, Jin M, Muhammad AKMG, Bell S, Landeros J, Valencia V, Harms M, Arditi M, Jefferies C, Baloh RH. McCauley ME, et al. Nature. 2020 Sep;585(7823):96-101. doi: 10.1038/s41586-020-2625-x. Epub 2020 Aug 19. Nature. 2020. PMID: 32814898 Free PMC article.
Expansions of a hexanucleotide repeat (GGGGCC) in the C9orf72 gene are the most common cause of familial ALS and FTD (C9-ALS/FTD), and lead to both repeat-containing RNA and dipeptide accumulation, coupled with decreased C9orf72 protein expression in brain and peripheral b …
Expansions of a hexanucleotide repeat (GGGGCC) in the C9orf72 gene are the most common cause of familial ALS and FTD (C9-ALS/FTD), and lead …
Proceedings of the 14th International Newborn Brain Conference: Neuro-imaging studies.
Herrera S, Herrera S, Cabacungan E, Cohen S, Thyagarajan B, Jefferies K, Avanaki K, Manwar R, McGuire L, Islam T, Shoo A, Charbel FT, Pillers DM, Verschuur A, van Steenis A, Boswinkel V, Nijholt I, Boomsma M, Steggerda S, Meijler G, Leijser L, Park SG, Yang HJ, Lim SY, Kim SH, Shin SH, Kim EK, Kim HS, Shiraki A, Kidokoro H, Watanabe H, Taga G, Narita H, Mitsumatsu T, Kumai S, Suzui R, Sawamura F, Ito Y, Yamamoto H, Nakata T, Sato Y, Hayakawa M, Natsume J, Buchmayer J, Kasprian G, Giordano V, Jernej R, Klebermass-Schrehof K, Berger A, Goeral K, Garvey A, El-Shibiny H, Yang E, Inder T, El-Dib M, Garvey A, Grant E, Manning S, Volpe J, Inder T, Roychaudhuri S, Pineda R, Sharon D, Singh E, Steele T, Sheldon Y, Cuddyer D, Yang E, Erdei C, Szakmar E, Andorka C, Barta H, Sesztak T, Varga E, Szabo M, Jermendy A, Panzarini I, King R, Verschuur AS, Hendson L, Carlson H, Scotland J, Zein H, Mohammed K, Meijler G, Leijser L, Bach A, Lambing H, Rogers EE, Xu D, James BA, Ferriero DM, Glass HC, Gano D, Igreja L, Ferreira A, Gomes R, Sousa B, Novo A, Alves JE, Proença E, Carvalho C. Herrera S, et al. J Neonatal Perinatal Med. 2023;16(s1):S75-S101. doi: 10.3233/NPM-239005. J Neonatal Perinatal Med. 2023. PMID: 37599544 No abstract available.
Pharmacokinetics, safety, and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial.
Hanna C, Kurian KM, Williams K, Watts C, Jackson A, Carruthers R, Strathdee K, Cruickshank G, Dunn L, Erridge S, Godfrey L, Jefferies S, McBain C, Sleigh R, McCormick A, Pittman M, Halford S, Chalmers AJ. Hanna C, et al. Neuro Oncol. 2020 Dec 18;22(12):1840-1850. doi: 10.1093/neuonc/noaa104. Neuro Oncol. 2020. PMID: 32347934 Free PMC article. Clinical Trial.
BACKGROUND: The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib potentiated radiation and temozolomide (TMZ) chemotherapy in preclinical glioblastoma models but brain penetration was poor. Clinically, PARP inhibitors exacerbate the hematological side effects of TMZ. …
BACKGROUND: The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib potentiated radiation and temozolomide (TMZ) chemotherapy in preclinic …
Evolving treatment options for melanoma brain metastases.
Ajithkumar T, Parkinson C, Fife K, Corrie P, Jefferies S. Ajithkumar T, et al. Lancet Oncol. 2015 Oct;16(13):e486-97. doi: 10.1016/S1470-2045(15)00141-2. Lancet Oncol. 2015. PMID: 26433822 Review.
Melanoma is a leading cause of lost productivity due to premature cancer mortality. Melanoma frequently spreads to the brain and is associated with rapid deterioration in quality and quantity of life. ...In this Review, we summarise evidence for the treatment of melanoma …
Melanoma is a leading cause of lost productivity due to premature cancer mortality. Melanoma frequently spreads to the brain and is a …
Adult brain tumour research in 2024: Status, challenges and recommendations.
Purshouse K, Bulbeck HJ, Rooney AG, Noble KE, Carruthers RD, Thompson G, Hamerlik P, Yap C, Kurian KM, Jefferies SJ, Lopez JS, Jenkinson MD, Hanemann CO, Stead LF. Purshouse K, et al. Neuropathol Appl Neurobiol. 2024 Apr;50(2):e12979. doi: 10.1111/nan.12979. Neuropathol Appl Neurobiol. 2024. PMID: 38605644 Review.
In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a brain tumour research task and finish group. ...We have identified seven universal brain tumour research priorities and three cros …
In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a b …
Brain tumor research in the United Kingdom: current perspective and future challenges. A strategy document from the NCRI Brain Tumor CSG.
Kurian KM, Jenkinson MD, Brennan PM, Grant R, Jefferies S, Rooney AG, Bulbeck H, Erridge SC, Mills S, McBain C, McCabe MG, Price SJ, Marino S, Moyes E, Qian W, Waldman A, Vaqas B, Keatley D, Burchill P, Watts C. Kurian KM, et al. Neurooncol Pract. 2018 Mar;5(1):10-17. doi: 10.1093/nop/npx022. Epub 2017 Aug 30. Neurooncol Pract. 2018. PMID: 31385960 Free PMC article. Review.
The National Cancer Research Institute (NCRI) is a partnership of charity and government research funders whose purpose is to improve health and quality of life by accelerating progress in cancer-related research through collaboration. Under this umbrella, the NCRI Brain T …
The National Cancer Research Institute (NCRI) is a partnership of charity and government research funders whose purpose is to improve health …
281 results