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Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies.
J Immunother Cancer. 2023 Dec 11;11(12):e007502. doi: 10.1136/jitc-2023-007502.
J Immunother Cancer. 2023.
PMID: 38081778
Free PMC article.
TIGIT Expression on Activated NK Cells Correlates with Greater Anti-Tumor Activity but Promotes Functional Decline upon Lung Cancer Exposure: Implications for Adoptive Cell Therapy and TIGIT-Targeted Therapies.
Hasan MF, Croom-Perez TJ, Oyer JL, Dieffenthaller TA, Robles-Carrillo LD, Eloriaga JE, Kumar S, Andersen BW, Copik AJ.
Hasan MF, et al. Among authors: andersen bw.
Cancers (Basel). 2023 May 11;15(10):2712. doi: 10.3390/cancers15102712.
Cancers (Basel). 2023.
PMID: 37345049
Free PMC article.
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