Abstract
Clinical signs appearance and significant increases of ICAM-1 and MMP-2 expressions with the clusters of VCAM-1(+) immunoreactivity in the choroids plexus epithelium to transferred anti-myelin oligodendroglial antibodies into the third brain ventricle, indicate important role of choroids plexus in the induction of acute experimental autoimmune encephalomyelitis (EAE). Magnetic brain stimulation with AKMA micro-magnet flux density of 60 miliTesla, 5 mm in diameter, implanted upon the pineal gland (PG), immediately after antibody injection, significantly decreases the expression of MMP-2 and ICAM-1 in the choroids plexus of the rat brain and abruptly suppresses the induction of acute EAE.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cell Adhesion / physiology*
-
Cell Count
-
Choroid Plexus / drug effects
-
Choroid Plexus / metabolism*
-
Deep Brain Stimulation*
-
Electrodes, Implanted
-
Encephalomyelitis, Autoimmune, Experimental / pathology
-
Encephalomyelitis, Autoimmune, Experimental / prevention & control*
-
Female
-
Image Processing, Computer-Assisted
-
Immunohistochemistry
-
Intercellular Adhesion Molecule-1 / biosynthesis*
-
Male
-
Matrix Metalloproteinase 2 / biosynthesis*
-
Myelin Sheath / metabolism
-
Oligodendroglia / pathology
-
Rats
-
Third Ventricle / metabolism
-
Up-Regulation
-
Vascular Cell Adhesion Molecule-1 / biosynthesis*
Substances
-
Vascular Cell Adhesion Molecule-1
-
Intercellular Adhesion Molecule-1
-
Matrix Metalloproteinase 2