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Page 1
Identification and Quantification of MIDD0301 Metabolites.
Curr Drug Metab. 2021;22(14):1114-1123. doi: 10.2174/1389200222666211202093841.
Curr Drug Metab. 2021.
PMID: 34856893
Free PMC article.
The Effects of pH on the Structure and Bioavailability of Imidazobenzodiazepine-3-Carboxylate MIDD0301.
Roni MSR, Li G, Mikulsky BN, Knutson DE, Mian MY, Zahn NM, Cook JM, Stafford DC, Arnold LA.
Roni MSR, et al. Among authors: mikulsky bn.
Mol Pharm. 2020 Apr 6;17(4):1182-1192. doi: 10.1021/acs.molpharmaceut.9b01210. Epub 2020 Feb 26.
Mol Pharm. 2020.
PMID: 32069056
Free PMC article.
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Targeting Nitric Oxide Production in Microglia with Novel Imidazodiazepines for Nonsedative Pain Treatment.
Nieman AN, Li G, Zahn NM, Mian MY, Mikulsky BN, Hoffman DA, Wilcox TM, Kehoe AS, Luecke IW, Poe MM, Alvarez-Carbonell D, Cook JM, Stafford DC, Arnold LA.
Nieman AN, et al. Among authors: mikulsky bn.
ACS Chem Neurosci. 2020 Jul 1;11(13):2019-2030. doi: 10.1021/acschemneuro.0c00324. Epub 2020 Jun 18.
ACS Chem Neurosci. 2020.
PMID: 32511908
Free PMC article.
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Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models.
Zahn NM, Mikulsky BN, Roni MSR, Yocum GT, Mian MY, Knutson DE, Cook JM, Emala CW, Stafford DC, Arnold LA.
Zahn NM, et al. Among authors: mikulsky bn.
ACS Pharmacol Transl Sci. 2020 Dec 2;3(6):1381-1390. doi: 10.1021/acsptsci.0c00180. eCollection 2020 Dec 11.
ACS Pharmacol Transl Sci. 2020.
PMID: 33344908
Free PMC article.
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MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABAA receptors without causing systemic immune suppression.
Zahn NM, Huber AT, Mikulsky BN, Stepanski ME, Kehoe AS, Li G, Schussman M, Rashid Roni MS, Kodali R, Cook JM, Stafford DC, Steeber DA, Arnold LA.
Zahn NM, et al. Among authors: mikulsky bn.
Basic Clin Pharmacol Toxicol. 2019 Jul;125(1):75-84. doi: 10.1111/bcpt.13206. Epub 2019 Feb 21.
Basic Clin Pharmacol Toxicol. 2019.
PMID: 30694594
Free PMC article.
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A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABAA Receptor.
Li G, Nieman AN, Mian MY, Zahn NM, Mikulsky BN, Poe MM, Methuku KR, Liu Y, Cook JM, Stafford DC, Arnold LA.
Li G, et al. Among authors: mikulsky bn.
Molecules. 2020 Aug 25;25(17):3864. doi: 10.3390/molecules25173864.
Molecules. 2020.
PMID: 32854311
Free PMC article.
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