Developmental Foot Deformities in Patients with Connective Tissue Disorders

JBJS Rev. 2023 Feb 17;11(2). doi: 10.2106/JBJS.RVW.22.00219. eCollection 2023 Feb 1.

Abstract

»: Foot deformities make up a large percentage of all orthopaedic complaints in patients with Down syndrome, Marfan syndrome, Ehlers-Danlos syndrome, Larsen syndrome, and osteogenesis imperfecta.

»: Some common causes of foot deformities in these conditions include increased ligament laxity, hypotonia, and hypermobility of the joints.

»: Treatment options for syndromic foot deformities include the use of foot orthoses, physical therapy, bracing, and various surgical procedures.

»: There is limited evidence supporting the use of surgical intervention to correct foot deformities associated with Down syndrome, Marfan syndrome, Ehlers-Danlos syndrome, Larsen syndrome, and osteogenesis imperfecta. Therefore, further research is needed to determine the short-term and long-term outcomes of these procedures.

MeSH terms

  • Connective Tissue
  • Connective Tissue Diseases* / complications
  • Down Syndrome* / complications
  • Ehlers-Danlos Syndrome* / complications
  • Foot Deformities* / complications
  • Foot Deformities* / surgery
  • Humans
  • Joint Instability*
  • Marfan Syndrome* / complications
  • Osteogenesis Imperfecta* / complications

Supplementary concepts

  • Larsen Syndrome