Baseline brain function in the preadolescents of the ABCD Study

B Chaarani; S Hahn; N Allgaier; S Adise; M M Owens; A C Juliano; D K Yuan; H Loso; A Ivanciu; M D Albaugh; J Dumas; S Mackey; J Laurent; M Ivanova; D J Hagler; M D Cornejo; S Hatton; A Agrawal; L Aguinaldo; L Ahonen; W Aklin; A P Anokhin; J Arroyo; S Avenevoli; D Babcock; K Bagot; F C Baker; M T Banich; D M Barch; H Bartsch; A Baskin-Sommers; J M Bjork; D Blachman-Demner; M Bloch; R Bogdan; S Y Bookheimer; F Breslin; S Brown; F J Calabro; V Calhoun; B J Casey; L Chang; D B Clark; C Cloak; R T Constable; K Constable; R Corley; L B Cottler; S Coxe; R K Dagher; A M Dale; M Dapretto; R Delcarmen-Wiggins; A S Dick; E K Do; N U F Dosenbach; G J Dowling; S Edwards; T M Ernst; D A Fair; C C Fan; E Feczko; S W Feldstein-Ewing; P Florsheim; J J Foxe; E G Freedman; N P Friedman; S Friedman-Hill; B F Fuemmeler; A Galvan; D G Gee; J Giedd; M Glantz; P Glaser; J Godino; M Gonzalez; R Gonzalez; S Grant; K M Gray; F Haist; M P Harms; S Hawes; A C Heath; S Heeringa; M M Heitzeg; R Hermosillo; M M Herting; J M Hettema; J K Hewitt; C Heyser; E Hoffman; K Howlett; R S Huber; M A Huestis; L W Hyde; W G Iacono; M A Infante; O Irfanoglu; A Isaiah; S Iyengar; J Jacobus; R James; B Jean-Francois; T Jernigan; N R Karcher; A Kaufman; B Kelley; B Kit; A Ksinan; J Kuperman; A R Laird; C Larson; K LeBlanc; C Lessov-Schlagger; N Lever; D A Lewis; K Lisdahl; A R Little; M Lopez; M Luciana; B Luna; P A Madden; H H Maes; C Makowski; A T Marshall; M J Mason; J Matochik; B D McCandliss; E McGlade; I Montoya; G Morgan; A Morris; C Mulford; P Murray; B J Nagel; M C Neale; G Neigh; A Nencka; A Noronha; S J Nixon; C E Palmer; V Pariyadath; M P Paulus; W E Pelham; D Pfefferbaum; C Pierpaoli; A Prescot; D Prouty; L I Puttler; N Rajapaske; K M Rapuano; G Reeves; P F Renshaw; M C Riedel; P Rojas; M de la Rosa; M D Rosenberg; M J Ross; M Sanchez; C Schirda; D Schloesser; J Schulenberg; K J Sher; C Sheth; P D Shilling; W K Simmons; E R Sowell; N Speer; M Spittel; L M Squeglia; C Sripada; J Steinberg; C Striley; M T Sutherland; J Tanabe; S F Tapert; W Thompson; R L Tomko; K A Uban; S Vrieze; N E Wade; R Watts; S Weiss; B A Wiens; O D Williams; A Wilbur; D Wing; D Wolff-Hughes; R Yang; D A Yurgelun-Todd; R A Zucker; A Potter; H P Garavan; ABCD Consortium

doi:10.1038/s41593-021-00867-9

Baseline brain function in the preadolescents of the ABCD Study

Nat Neurosci. 2021 Aug;24(8):1176-1186. doi: 10.1038/s41593-021-00867-9. Epub 2021 Jun 7.

Authors

B Chaarani¹, S Hahn², N Allgaier², S Adise², M M Owens², A C Juliano², D K Yuan², H Loso², A Ivanciu², M D Albaugh², J Dumas², S Mackey², J Laurent², M Ivanova², D J Hagler³, M D Cornejo⁴, S Hatton³, A Agrawal⁵, L Aguinaldo³, L Ahonen⁶, W Aklin⁷, A P Anokhin⁵, J Arroyo⁸, S Avenevoli⁹, D Babcock¹⁰, K Bagot¹¹, F C Baker¹², M T Banich¹³, D M Barch⁵, H Bartsch¹⁴, A Baskin-Sommers¹⁵, J M Bjork¹⁶, D Blachman-Demner¹⁷, M Bloch¹⁸, R Bogdan⁵, S Y Bookheimer¹⁹, F Breslin²⁰, S Brown³, F J Calabro⁶, V Calhoun^{13

21}, B J Casey¹⁵, L Chang²², D B Clark⁶, C Cloak²², R T Constable¹⁵, K Constable⁷, R Corley¹³, L B Cottler²³, S Coxe²⁴, R K Dagher²⁵, A M Dale³, M Dapretto¹⁹, R Delcarmen-Wiggins²⁶, A S Dick²⁴, E K Do¹⁶, N U F Dosenbach⁵, G J Dowling⁷, S Edwards²², T M Ernst²², D A Fair²⁷, C C Fan⁵, E Feczko²⁷, S W Feldstein-Ewing²⁷, P Florsheim²⁸, J J Foxe²⁹, E G Freedman²⁹, N P Friedman¹³, S Friedman-Hill⁹, B F Fuemmeler¹⁶, A Galvan¹⁹, D G Gee¹⁵, J Giedd³, M Glantz⁷, P Glaser⁵, J Godino³, M Gonzalez³⁰, R Gonzalez²⁴, S Grant⁷, K M Gray³¹, F Haist³, M P Harms⁵, S Hawes²⁴, A C Heath³, S Heeringa³², M M Heitzeg³², R Hermosillo²⁷, M M Herting³³, J M Hettema¹⁶, J K Hewitt¹³, C Heyser³, E Hoffman⁷, K Howlett⁷, R S Huber³⁴, M A Huestis³⁵, L W Hyde³², W G Iacono³⁶, M A Infante³, O Irfanoglu³⁷, A Isaiah²², S Iyengar³⁸, J Jacobus³, R James¹⁶, B Jean-Francois²⁵, T Jernigan³, N R Karcher⁵, A Kaufman¹⁸, B Kelley³⁹, B Kit⁴⁰, A Ksinan¹⁶, J Kuperman³, A R Laird²⁴, C Larson²⁸, K LeBlanc⁷, C Lessov-Schlagger⁵, N Lever²², D A Lewis⁶, K Lisdahl²⁸, A R Little⁷, M Lopez⁷, M Luciana³⁶, B Luna⁶, P A Madden⁵, H H Maes¹⁶, C Makowski³, A T Marshall³⁰, M J Mason⁴¹, J Matochik⁸, B D McCandliss⁴², E McGlade³⁴, I Montoya⁷, G Morgan¹⁸, A Morris⁴³, C Mulford⁷, P Murray⁸, B J Nagel²⁷, M C Neale¹⁶, G Neigh¹⁶, A Nencka⁴⁴, A Noronha⁸, S J Nixon²³, C E Palmer³, V Pariyadath⁷, M P Paulus²⁰, W E Pelham²⁴, D Pfefferbaum¹², C Pierpaoli⁴⁵, A Prescot³⁴, D Prouty¹², L I Puttler³², N Rajapaske²⁵, K M Rapuano¹⁵, G Reeves²², P F Renshaw³⁴, M C Riedel²⁴, P Rojas²⁴, M de la Rosa²⁴, M D Rosenberg⁴⁶, M J Ross⁴⁷, M Sanchez²⁴, C Schirda⁶, D Schloesser¹⁷, J Schulenberg³², K J Sher⁴⁸, C Sheth³⁴, P D Shilling³, W K Simmons²⁰, E R Sowell³⁰, N Speer¹³, M Spittel¹⁷, L M Squeglia³¹, C Sripada³², J Steinberg¹⁶, C Striley²³, M T Sutherland²⁴, J Tanabe¹³, S F Tapert³, W Thompson³, R L Tomko³¹, K A Uban⁴⁹, S Vrieze³⁶, N E Wade³, R Watts¹⁵, S Weiss⁷, B A Wiens²³, O D Williams²⁴, A Wilbur¹², D Wing³, D Wolff-Hughes¹⁷, R Yang³, D A Yurgelun-Todd³⁴, R A Zucker³², A Potter², H P Garavan⁵⁰; ABCD Consortium

Affiliations

¹ Department of Psychiatry, University of Vermont, Burlington, VT, USA. melmarsr@uvm.edu.
² Department of Psychiatry, University of Vermont, Burlington, VT, USA.
³ University of California, San Diego, La Jolla, CA, USA.
⁴ Institute of Physics UC, Pontificia Universidad Catolica de Chile, Pontificia, Chile.
⁵ Department of Psychiatry, Washington University in Saint Louis, St. Louis, MO, USA.
⁶ University of Pittsburgh, Pittsburgh, PA, USA.
⁷ National Institute on Drug Abuse, Bethesda, MD, USA.
⁸ National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
⁹ National Institute of Mental Health, Bethesda, MD, USA.
¹⁰ National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
¹¹ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹² SRI International, Menlo Park, CA, USA.
¹³ University of Colorado, Boulder, CO, USA.
¹⁴ Haukeland University Hospital, Bergen, Norway.
¹⁵ Yale University, New Haven, CT, USA.
¹⁶ Virginia Commonwealth University, Richmond, VA, USA.
¹⁷ NIH Office of Behavioral and Social Sciences Research, Bethesda, MD, USA.
¹⁸ National Cancer Institute, Bethesda, MD, USA.
¹⁹ University of California, Los Angeles, CA, USA.
²⁰ Laureate Institute for Brain Research, Tulsa, OK, USA.
²¹ Tri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
²² University of Maryland School of Medicine, Baltimore, MD, USA.
²³ University of Florida, Gainesville, FL, USA.
²⁴ Florida International University, Miami, FL, USA.
²⁵ National Institute on Minority Health and Health Disparities, Bethesda, MD, USA.
²⁶ NIH Office of Research on Women's Health, Bethesda, MD, USA.
²⁷ Oregon Health & Science University, Portland, OR, USA.
²⁸ University of Wisconsin, Milwaukee, WI, USA.
²⁹ University of Rochester, Rochester, NY, USA.
³⁰ Children's Hospital Los Angeles, Los Angeles, CA, USA.
³¹ Medical University of South Carolina, Charleston, SC, USA.
³² University of Michigan, Ann Arbor, MI, USA.
³³ University of Southern California, Los Angeles, CA, USA.
³⁴ University of Utah, Salt Lake City, UT, USA.
³⁵ Thomas Jefferson University, Philadelphia, PA, USA.
³⁶ University of Minnesota, Minneapolis, MN, USA.
³⁷ National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA.
³⁸ National Endowment for the Arts, Washington DC, USA.
³⁹ National Institute of Justice, Washington DC, USA.
⁴⁰ National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
⁴¹ University of Tennessee, Knoxville, TN, USA.
⁴² Stanford University, Stanford, CA, USA.
⁴³ Oklahoma State University, Stillwater, OK, USA.
⁴⁴ Medical College of Wisconsin, Milwaukee, WI, USA.
⁴⁵ Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
⁴⁶ University of Chicago, Chicago, IL, USA.
⁴⁷ University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁴⁸ University of Missouri, Columbia, MO, USA.
⁴⁹ University of California, Irvine, CA, USA.
⁵⁰ Department of Psychiatry, University of Vermont, Burlington, VT, USA. hgaravan@uvm.edu.

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study^® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N = 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N = 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adolescent
Adolescent Development / physiology
Brain / physiology*
Child
Female
Humans
Magnetic Resonance Imaging
Male
Reference Values

Abstract

Publication types

MeSH terms

Grants and funding