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Showing results for b xu he
Search for Bo-Xun Ke instead (1 results)
Conserved class B GPCR activation by a biased intracellular agonist.
Zhao LH, He Q, Yuan Q, Gu Y, He X, Shan H, Li J, Wang K, Li Y, Hu W, Wu K, Shen J, Xu HE. Zhao LH, et al. Among authors: xu he. Nature. 2023 Sep;621(7979):635-641. doi: 10.1038/s41586-023-06467-w. Epub 2023 Jul 31. Nature. 2023. PMID: 37524305
Class B G-protein-coupled receptors (GPCRs), including glucagon-like peptide 1 receptor (GLP1R) and parathyroid hormone 1 receptor (PTH1R), are important drug targets(1-5). ...These insights should facilitate the design of distinct types of class B GPCR small-molecu …
Class B G-protein-coupled receptors (GPCRs), including glucagon-like peptide 1 receptor (GLP1R) and parathyroid hormone 1 receptor (P …
ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery.
Guo CC, Xu HE, Ma X. Guo CC, et al. Among authors: xu he. Acta Pharmacol Sin. 2023 Nov;44(11):2139-2150. doi: 10.1038/s41401-023-01134-2. Epub 2023 Jul 24. Acta Pharmacol Sin. 2023. PMID: 37488425 Review.
In this article we provide an overview of the ARID family, focusing on the structure and biological functions of ARID3a. It explores the role of ARID3a in autoreactive B cells and its contribution to autoimmune diseases such as systemic lupus erythematosus and primary bili …
In this article we provide an overview of the ARID family, focusing on the structure and biological functions of ARID3a. It explores the rol …
Identification of potential ferroptosis-associated biomarkers in rheumatoid arthritis.
He X, Zhang J, Gong M, Gu Y, Dong B, Pang X, Zhang C, Cui Y. He X, et al. Front Immunol. 2023 Jul 10;14:1197275. doi: 10.3389/fimmu.2023.1197275. eCollection 2023. Front Immunol. 2023. PMID: 37492576 Free PMC article.
RESULTS: Three hub genes PTGS2, ENO1, and GRN highly associated with ferroptosis were identified. Four pathogenic genes HLA-B, MIF, PSTPIP, TLR1 were identified that were significantly and positively correlated with the expression levels of hub genes. ...
RESULTS: Three hub genes PTGS2, ENO1, and GRN highly associated with ferroptosis were identified. Four pathogenic genes HLA-B, MIF, P …
Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors.
Pal K, Melcher K, Xu HE. Pal K, et al. Among authors: xu he. Acta Pharmacol Sin. 2012 Mar;33(3):300-11. doi: 10.1038/aps.2011.170. Epub 2012 Jan 23. Acta Pharmacol Sin. 2012. PMID: 22266723 Free PMC article. Review.
Class B G-protein-coupled receptors (GPCRs) are receptors for peptide hormones that include glucagon, parathyroid hormone, and calcitonin. ...Although the structure of the full-length receptor remains unknown, the ECD structures have been well characterized for a number of …
Class B G-protein-coupled receptors (GPCRs) are receptors for peptide hormones that include glucagon, parathyroid hormone, and calcit …
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists.
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C. Sun W, et al. Among authors: xu he. Cell Discov. 2023 Jun 30;9(1):66. doi: 10.1038/s41421-023-00564-w. Cell Discov. 2023. PMID: 37391393 Free PMC article.
Neurokinin 3 receptor (NK3R) is a tachykinin receptor essential for the hypothalamic-pituitary-gonadal axis. The endogenous peptide agonist neurokinin B (NKB) preferentially activates NK3R, while substance P (SP) binds preferentially to NK1R. ...
Neurokinin 3 receptor (NK3R) is a tachykinin receptor essential for the hypothalamic-pituitary-gonadal axis. The endogenous peptide agonist …
B cell reconstitution following alemtuzumab induction under a belatacept-based maintenance regimen.
Xu H, Mehta AK, Gao Q, Lee HJ, Ghali A, Guasch A, Kirk AD. Xu H, et al. Am J Transplant. 2020 Mar;20(3):653-662. doi: 10.1111/ajt.15639. Epub 2019 Nov 13. Am J Transplant. 2020. PMID: 31596034 Free PMC article.
Alemtuzumab induction produced pan-lymphocyte depletion; B cells repopulated faster and more completely than T cells. Reconstituting B cells were predominantly naive, and memory B cells were significantly reduced (P = .001) post repopulation. ...These finding …
Alemtuzumab induction produced pan-lymphocyte depletion; B cells repopulated faster and more completely than T cells. Reconstituting …
116 results