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Showing results for bystander singh
Search for Bishander Singh instead (2 results)
Pancreatic islet-specific engineered T(regs) exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models.
Yang SJ, Singh AK, Drow T, Tappen T, Honaker Y, Barahmand-Pour-Whitman F, Linsley PS, Cerosaletti K, Mauk K, Xiang Y, Smith J, Mortensen E, Cook PJ, Sommer K, Khan I, Liggitt D, Rawlings DJ, Buckner JH. Yang SJ, et al. Sci Transl Med. 2022 Oct 5;14(665):eabn1716. doi: 10.1126/scitranslmed.abn1716. Epub 2022 Oct 5. Sci Transl Med. 2022. PMID: 36197963
EngT(regs) suppressed T(effs) recognizing the same islet antigen in addition to bystander T(effs) recognizing other islet antigens through production of soluble mediators and both direct and indirect mechanisms. ...
EngT(regs) suppressed T(effs) recognizing the same islet antigen in addition to bystander T(effs) recognizing other islet antigens th …
Characterizing the regulatory Fas (CD95) epitope critical for agonist antibody targeting and CAR-T bystander function in ovarian cancer.
Mondal T, Gaur H, Wamba BEN, Michalak AG, Stout C, Watson MR, Aleixo SL, Singh A, Condello S, Faller R, Leiserowitz GS, Bhatnagar S, Tushir-Singh J. Mondal T, et al. Cell Death Differ. 2023 Nov;30(11):2408-2431. doi: 10.1038/s41418-023-01229-7. Epub 2023 Oct 14. Cell Death Differ. 2023. PMID: 37838774 Free PMC article.
PPCR engagement is indispensable for superior Fas agonist signaling and CAR-T bystander function in ovarian tumor models. A single-point mutation in FasL or Fas that interferes with the PPCR engagement inhibited apoptotic signaling in tumor cells and T cells. Furthermore, …
PPCR engagement is indispensable for superior Fas agonist signaling and CAR-T bystander function in ovarian tumor models. A single-po …
Cytomegalovirus in ulcerative colitis: an evidence-based approach to diagnosis and treatment.
Jena A, Mishra S, Singh AK, Sekar A, Sharma V. Jena A, et al. Expert Rev Gastroenterol Hepatol. 2022 Feb;16(2):109-120. doi: 10.1080/17474124.2022.2032662. Epub 2022 Jan 31. Expert Rev Gastroenterol Hepatol. 2022. PMID: 35057693 Review.
INTRODUCTION: The detection of cytomegalovirus (CMV) in the setting of inflammatory bowel disease often creates confusion whether CMV is a 'bystander' or 'disease.' AREAS COVERED: This review discusses the clinical conundrum of CMV in ulcerative colitis, approach to discri …
INTRODUCTION: The detection of cytomegalovirus (CMV) in the setting of inflammatory bowel disease often creates confusion whether CMV is a ' …
IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.
Ab O, Whiteman KR, Bartle LM, Sun X, Singh R, Tavares D, LaBelle A, Payne G, Lutz RJ, Pinkas J, Goldmacher VS, Chittenden T, Lambert JM. Ab O, et al. Mol Cancer Ther. 2015 Jul;14(7):1605-13. doi: 10.1158/1535-7163.MCT-14-1095. Epub 2015 Apr 22. Mol Cancer Ther. 2015. PMID: 25904506
IMGN853 displayed cytotoxic activity against FRalpha-negative cells situated near FRalpha-positive cells (bystander cytotoxic activity), indicating its ability to eradicate tumors with heterogeneous expression of FRalpha. ...
IMGN853 displayed cytotoxic activity against FRalpha-negative cells situated near FRalpha-positive cells (bystander cytotoxic activit …
In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates.
Wang C, Thudium KB, Han M, Wang XT, Huang H, Feingersh D, Garcia C, Wu Y, Kuhne M, Srinivasan M, Singh S, Wong S, Garner N, Leblanc H, Bunch RT, Blanset D, Selby MJ, Korman AJ. Wang C, et al. Cancer Immunol Res. 2014 Sep;2(9):846-56. doi: 10.1158/2326-6066.CIR-14-0040. Epub 2014 May 28. Cancer Immunol Res. 2014. PMID: 24872026
The programmed death-1 (PD-1) receptor serves as an immunologic checkpoint, limiting bystander tissue damage and preventing the development of autoimmunity during inflammatory responses. ...
The programmed death-1 (PD-1) receptor serves as an immunologic checkpoint, limiting bystander tissue damage and preventing the devel …
36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.
Bateman RM, Sharpe MD, Jagger JE, Ellis CG, Solé-Violán J, López-Rodríguez M, Herrera-Ramos E, Ruíz-Hernández J, Borderías L, Horcajada J, González-Quevedo N, Rajas O, Briones M, Rodríguez de Castro F, Rodríguez Gallego C, Esen F, Orhun G, Ergin Ozcan P, Senturk E, Ugur Yilmaz C, Orhan N, Arican N, Kaya M, Kucukerden M, Giris M, Akcan U, Bilgic Gazioglu S, Tuzun E, Riff R, Naamani O, Douvdevani A, Takegawa R, Yoshida H, Hirose T, Yamamoto N, Hagiya H, Ojima M, Akeda Y, Tasaki O, Tomono K, Shimazu T, Ono S, Kubo T, Suda S, Ueno T, Ikeda T, Hirose T, Ogura H, Takahashi H, Ojima M, Kang J, Nakamura Y, Kojima T, Shimazu T, Ikeda T, Suda S, Izutani Y, Ueno T, Ono S, Taniguchi T, O M, Dinter C, Lotz J, Eilers B, Wissmann C, Lott R, Meili MM, Schuetz PS, Hawa H, Sharshir M, Aburageila M, Salahuddin N, Chantziara V, Georgiou S, Tsimogianni A, Alexandropoulos P, Vassi A, Lagiou F, Valta M, Micha G, Chinou E, Michaloudis G, Kodaira A, Ikeda T, Ono S, Ueno T, Suda S, Izutani Y, Imaizumi H, De la Torre-Prados MV, Garcia-De la Torre A, Enguix-Armada A, Puerto-Morlan A, Perez-Valero V, Garcia-Alcantara A, Bolton N, Dudziak J, Bonney S, Tridente A, Nee P, Nicolaes G, Wiewel M, Schultz M, Wildhag… See abstract for full author list ➔ Bateman RM, et al. Crit Care. 2016 Apr 20;20(Suppl 2):94. doi: 10.1186/s13054-016-1208-6. Crit Care. 2016. PMID: 27885969 Free PMC article.
Hanoura, S. Sudarsanan, P. Sivadasan, H. Othamn, Y. Shouman, R. Singh, A. Al Khulaifi P142 - Complex evaluation of endothelial dysfunction markers for prognosis of outcomes in patients undergoing cardiac surgery I. ...Hanoura , A. Omar, H. Othamn, S. Sudarsanan , M. Allam, …
Hanoura, S. Sudarsanan, P. Sivadasan, H. Othamn, Y. Shouman, R. Singh, A. Al Khulaifi P142 - Complex evaluation of endothelial dysfun …
Quantitative characterization of in vitro bystander effect of antibody-drug conjugates.
Singh AP, Sharma S, Shah DK. Singh AP, et al. J Pharmacokinet Pharmacodyn. 2016 Dec;43(6):567-582. doi: 10.1007/s10928-016-9495-8. Epub 2016 Sep 26. J Pharmacokinet Pharmacodyn. 2016. PMID: 27670282 Free PMC article.
This additional efficacy of ADCs on Ag- cells in the presence of Ag+ cells is known as the 'bystander effect'. Although the importance of this phenomena is widely acknowledged for effective killing of a heterogeneous tumor, the rate and extent of the bystander killi …
This additional efficacy of ADCs on Ag- cells in the presence of Ag+ cells is known as the 'bystander effect'. Although the importanc …
Fungal Pathogens in CF Airways: Leave or Treat?
Singh A, Ralhan A, Schwarz C, Hartl D, Hector A. Singh A, et al. Mycopathologia. 2018 Feb;183(1):119-137. doi: 10.1007/s11046-017-0184-y. Epub 2017 Aug 2. Mycopathologia. 2018. PMID: 28770417 Review.
However, it remains elusive whether fungi are actively involved in CF lung disease pathologies or whether they rather reflect a dysregulated airway colonization and act as microbial bystanders. A key issue for dissecting the role of fungi in CF lung disease is the distinct …
However, it remains elusive whether fungi are actively involved in CF lung disease pathologies or whether they rather reflect a dysregulated …
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