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Showing results for bingeing ding
Search for Bingying Ding instead (2 results)
Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice.
Chao X, Wang S, Zhao K, Li Y, Williams JA, Li T, Chavan H, Krishnamurthy P, He XC, Li L, Ballabio A, Ni HM, Ding WX. Chao X, et al. Gastroenterology. 2018 Sep;155(3):865-879.e12. doi: 10.1053/j.gastro.2018.05.027. Epub 2018 May 18. Gastroenterology. 2018. PMID: 29782848 Free PMC article.
Mice were placed on diets of regular ethanol feeding plus an acute binge to induce liver damage (ethanol diet); some mice also were given injections of torin-1, an inhibitor of the kinase activity of the mechanistic target of rapamycin (mTOR). ...Liver tissues from patient …
Mice were placed on diets of regular ethanol feeding plus an acute binge to induce liver damage (ethanol diet); some mice also were g …
Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation.
Ma X, Chen A, Melo L, Clemente-Sanchez A, Chao X, Ahmadi AR, Peiffer B, Sun Z, Sesaki H, Li T, Wang X, Liu W, Bataller R, Ni HM, Ding WX. Ma X, et al. Hepatology. 2023 Jan 1;77(1):159-175. doi: 10.1002/hep.32604. Epub 2022 Jul 5. Hepatology. 2023. PMID: 35698731 Free PMC article.
Liver-specific dynamin-related protein 1 (DRP1; gene name DNM1L, an essential gene regulating mitochondria fission ) knockout (L-DRP1 KO) mice and wild-type mice were subjected to chronic plus binge alcohol feeding. Both human AH and alcohol-fed mice had decreased hepatic …
Liver-specific dynamin-related protein 1 (DRP1; gene name DNM1L, an essential gene regulating mitochondria fission ) knockout (L-DRP1 KO) mi …
Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis.
Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B, Wang H. Ren R, et al. Hepatology. 2022 Mar;75(3):646-660. doi: 10.1002/hep.32152. Epub 2021 Dec 5. Hepatology. 2022. PMID: 34510484 Free PMC article.
APPROACH AND RESULTS: Young and aged myeloid-specific Sirt1 knockout mice were subjected to chronic-plus-binge ethanol feeding. Blood samples from healthy controls and patients with chronic alcohol drinking who presented with acute intoxication were analyzed. ...Deletion o …
APPROACH AND RESULTS: Young and aged myeloid-specific Sirt1 knockout mice were subjected to chronic-plus-binge ethanol feeding. Blood …
Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis.
Chao X, Wang S, Ma X, Zhang C, Qian H, Williams SN, Sun Z, Peng Z, Liu W, Li F, Sheshadri N, Zong WX, Ni HM, Ding WX. Chao X, et al. Hepatology. 2023 Aug 1;78(2):503-517. doi: 10.1097/HEP.0000000000000373. Epub 2023 Apr 1. Hepatology. 2023. PMID: 36999531
Gao-binge alcohol markedly increased liver/body weight ratio and serum alanine aminotransferase levels in L- Tsc1 KO mice compared with Gao-binge alcohol-fed wild-type mice. ...Gao-binge alcohol-fed L- Tsc1 KO mice also developed severe inflammation and liver …
Gao-binge alcohol markedly increased liver/body weight ratio and serum alanine aminotransferase levels in L- Tsc1 KO mice compared wi …
Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease.
Ding C, Ng Fat L, Britton A, Im PK, Lin K, Topiwala A, Li L, Chen Z, Millwood IY, Bell S, Mehta G. Ding C, et al. Nat Commun. 2023 Dec 14;14(1):8041. doi: 10.1038/s41467-023-43064-x. Nat Commun. 2023. PMID: 38097541 Free PMC article.
Further, we demonstrate a pronounced interaction between heavy binge drinking and high PRS, resulting in a relative excess risk due to interaction (RERI) of 6.07. Diabetes consistently elevates ARC risk across all drinking and PRS categories, and showed significant interac …
Further, we demonstrate a pronounced interaction between heavy binge drinking and high PRS, resulting in a relative excess risk due t …
NAD Supplement Alleviates Intestinal Barrier Injury Induced by Ethanol Via Protecting Epithelial Mitochondrial Function.
Li W, Zhou Y, Pang N, Hu Q, Li Q, Sun Y, Ding Y, Gu Y, Xiao Y, Gao M, Ma S, Pan J, Fang EF, Zhang Z, Yang L. Li W, et al. Nutrients. 2022 Dec 30;15(1):174. doi: 10.3390/nu15010174. Nutrients. 2022. PMID: 36615829 Free PMC article.
However, whether NR can prevent ethanol-induced intestinal barrier dysfunction and the underlying mechanisms remain unclear. METHODS: We applied the mouse NIAAA model (chronic plus binge ethanol feeding) and Caco-2 cells to explore the effects of NR on ethanol-induced inte …
However, whether NR can prevent ethanol-induced intestinal barrier dysfunction and the underlying mechanisms remain unclear. METHODS: We app …
Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-Induced Liver Injury in Aged Mice.
Qian H, Chao X, Wang S, Li Y, Jiang X, Sun Z, Rülicke T, Zatloukal K, Ni HM, Ding WX. Qian H, et al. Cell Mol Gastroenterol Hepatol. 2023;15(5):1027-1049. doi: 10.1016/j.jcmgh.2023.01.016. Epub 2023 Feb 7. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36754207 Free PMC article.
METHODS: Young and aged whole-body SQSTM1/p62 knockout (KO) and their age-matched wild-type (WT) mice were subjected to chronic plus binge (Gao-binge) alcohol feeding. Blood, adipose and liver tissues were collected for biochemical and histologic analysis. ...SQSTM1 …
METHODS: Young and aged whole-body SQSTM1/p62 knockout (KO) and their age-matched wild-type (WT) mice were subjected to chronic plus bing …
Demographic and behavioural correlates of energy drink consumption.
Markon AO, Ding M, Chavarro JE, Wolpert BJ. Markon AO, et al. Public Health Nutr. 2023 Jul;26(7):1424-1435. doi: 10.1017/S1368980022001902. Epub 2022 Oct 10. Public Health Nutr. 2023. PMID: 36214079 Free PMC article.
DESIGN: We conducted cross-sectional analysis including basic descriptive and multivariable-adjusted logistic regression analyses to characterise demographic and behavioural factors (including diet quality, binge drinking and illicit drug use, among others obtained via que …
DESIGN: We conducted cross-sectional analysis including basic descriptive and multivariable-adjusted logistic regression analyses to charact …
The role of MLKL in Hepatic Ischemia-Reperfusion Injury of Alcoholic Steatotic Livers.
Chen H, McKeen T, Chao X, Chen A, Deng F, Jaeschke H, Ding WX, Ni HM. Chen H, et al. Int J Biol Sci. 2022 Jan 1;18(3):1096-1106. doi: 10.7150/ijbs.67533. eCollection 2022. Int J Biol Sci. 2022. PMID: 35173541 Free PMC article.
Though necroptosis plays an important role in IR injury of high fat diet - induced steatotic livers, the role of necroptosis in IR injury of ethanol - induced steototic livers has not been investigated. In the present study, we used chronic plus binge alcohol (Gao-binge …
Though necroptosis plays an important role in IR injury of high fat diet - induced steatotic livers, the role of necroptosis in IR injury of …
Activated and nonactivated MSCs increase survival in humanized mice after acute liver injury through alcohol binging.
Hernandez JC, Yeh DW, Marh J, Choi HY, Kim J, Chopra S, Ding L, Thornton M, Grubbs B, Makowka L, Sher L, Machida K. Hernandez JC, et al. Hepatol Commun. 2022 Jul;6(7):1549-1560. doi: 10.1002/hep4.1924. Epub 2022 Mar 5. Hepatol Commun. 2022. PMID: 35246968 Free PMC article.
To induce liver injury, humanized mice were fed high-cholesterol high-fat liquid diet with alcohol binge drinking. Mice were then treated with either umbilical cord MSCs, activated umbilical cord MSCs, or a placebo and followed for survival. Blood samples were obtained at …
To induce liver injury, humanized mice were fed high-cholesterol high-fat liquid diet with alcohol binge drinking. Mice were then tre …
42 results