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Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells.
Gerecke C, Schumacher F, Edlich A, Wetzel A, Yealland G, Neubert LK, Scholtka B, Homann T, Kleuser B. Gerecke C, et al. Among authors: scholtka b. Oncotarget. 2018 Aug 28;9(67):32822-32840. doi: 10.18632/oncotarget.25999. eCollection 2018 Aug 28. Oncotarget. 2018. PMID: 30214687 Free PMC article.
LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability.
Melcher R, Hartmann E, Zopf W, Herterich S, Wilke P, Müller L, Rosler E, Kudlich T, Al-Taie O, Rosenwald A, Katzenberger T, Scholtka B, Seibold S, Rogoll D, Scheppach W, Scheurlen M, Lührs H. Melcher R, et al. Among authors: scholtka b. Carcinogenesis. 2011 Apr;32(4):636-42. doi: 10.1093/carcin/bgr011. Epub 2011 Feb 4. Carcinogenesis. 2011. PMID: 21297112