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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10.
J Immunother Cancer. 2020 May;8(1):e000599. doi: 10.1136/jitc-2020-000599.
J Immunother Cancer. 2020.
PMID: 32461349
Free PMC article.
Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population.
Stellas D, Karaliota S, Stravokefalou V, Angel M, Nagy BA, Goldfarbmuren KC, Bergamaschi C, Felber BK, Pavlakis GN.
Stellas D, et al. Among authors: nagy ba.
Cell Rep. 2023 May 30;42(5):112501. doi: 10.1016/j.celrep.2023.112501. Epub 2023 May 12.
Cell Rep. 2023.
PMID: 37178117
Free PMC article.
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Regression and Eradication of Triple-Negative Breast Carcinoma in 4T1 Mouse Model by Combination Immunotherapies.
Nahar S, Huang Y, Nagy BA, Zebala JA, Maeda DY, Rudloff U, Oppenheim JJ, Yang D.
Nahar S, et al. Among authors: nagy ba.
Cancers (Basel). 2023 Apr 19;15(8):2366. doi: 10.3390/cancers15082366.
Cancers (Basel). 2023.
PMID: 37190294
Free PMC article.
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Extracellular Matrix Scaffold-Assisted Tumor Vaccines Induce Tumor Regression and Long-Term Immune Memory.
Pal S, Chaudhari R, Baurceanu I, Hill BJ, Nagy BA, Wolf MT.
Pal S, et al. Among authors: nagy ba.
Adv Mater. 2024 Apr;36(15):e2309843. doi: 10.1002/adma.202309843. Epub 2024 Feb 11.
Adv Mater. 2024.
PMID: 38302823
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Heterodimeric IL-15 (hetIL-15) reduces circulating tumor cells and metastasis formation improving chemotherapy and surgery in 4T1 mouse model of TNBC.
Stravokefalou V, Stellas D, Karaliota S, Nagy BA, Valentin A, Bergamaschi C, Dimas K, Pavlakis GN.
Stravokefalou V, et al. Among authors: nagy ba.
Front Immunol. 2023 Jan 13;13:1014802. doi: 10.3389/fimmu.2022.1014802. eCollection 2022.
Front Immunol. 2023.
PMID: 36713398
Free PMC article.
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Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion.
Ng SSM, Nagy BA, Jensen SM, Hu X, Alicea C, Fox BA, Felber BK, Bergamaschi C, Pavlakis GN.
Ng SSM, et al. Among authors: nagy ba.
Clin Cancer Res. 2017 Jun 1;23(11):2817-2830. doi: 10.1158/1078-0432.CCR-16-1808. Epub 2016 Dec 16.
Clin Cancer Res. 2017.
PMID: 27986749
Free PMC article.
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