Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia.
Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, Bernhard O, Balleiniger M, Alfar EA, Zieseniss A, Toischer K, Guan K, Rizzoli SO, Brügger B, Fischer A, Katschinski DM, Rehling P, Dudek J.
Chowdhury A, et al.
Cell Rep. 2018 Oct 16;25(3):561-570.e6. doi: 10.1016/j.celrep.2018.09.057.
Cell Rep. 2018.
PMID: 30332638
Free PMC article.
Tafazzin deficiency does not affect posttranslational HIF-1alpha regulation but rather HIF-1alpha gene expression, a dysfunction recapitulated in iPSC-derived cardiomyocytes from Barth syndrome patients with tafazzin deficiency. RNA-seq analyses confirmed drastically alter …
Tafazzin deficiency does not affect posttranslational HIF-1alpha regulation but rather HIF-1alpha gene expression, a dysfunction recapitulat …